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    [{"orgOrder":0,"company":"Seelos Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Trehalose API","moa":"","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Seelos Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"","sponsorNew":"Seelos Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"8","companyTruncated":"Seelos Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Seelos Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"U.S.A","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Trehalose API","moa":"Autophagy","graph1":"Genetic Disease","graph2":"Phase II","graph3":"Seelos 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Diseases","amount2New":0,"dosageForm":"Gum, Chewing","sponsorNew":"NOVOS \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"NOVOS \/ Not Applicable"}]

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    01

    Seelos Therapeutics

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    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Study Phase : Phase II/ Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Seelos Provides Update on Top-Line Results from ALS Study with SLS-005 (IV Trehalose)

    Details : SLS-005 (trehalose), a low molecular weight disaccharide that stabilizes misfolded proteins and activates autophagy. It is being evaluated for the treatment of amyotrophic lateral sclerosis.

    Product Name : SLS-005

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    March 19, 2024

    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Highest Development Status : Phase II/ Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    NOVOS

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    Lead Product(s) : Trehalose API,Nattokinase,Rutin

    Therapeutic Area : Cardiology/Vascular Diseases

    Study Phase : Approved

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    NOVOS Launches Daily Chew to Optimize and Maintain Essential Organ Function

    Details : Novos vital is a groundbreaking supplement chew scientifically formulated with an ingredient blend shown to support and optimize essential organ functions that decline with age.

    Product Name : Novos Vital

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    February 21, 2024

    Lead Product(s) : Trehalose API,Nattokinase,Rutin

    Therapeutic Area : Cardiology/Vascular Diseases

    Highest Development Status : Approved

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics

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    Lead Product(s) : Trehalose API

    Therapeutic Area : Genetic Disease

    Study Phase : Phase II/ Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics Doses First Patient in a Registrational Phase II/III study of SLS-005 in Spinocerebellar A...

    Details : SLS-005 (trehalose) is a low molecular weight disaccharide that crosses the blood brain barrier and is thought to stabilize proteins and activate autophagy through the activation of Transcription Factor EB (TFEB), a key factor in lysosomal and autophagy ...

    Product Name : SLS-005

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    October 25, 2022

    Lead Product(s) : Trehalose API

    Therapeutic Area : Genetic Disease

    Highest Development Status : Phase II/ Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics

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    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Study Phase : Phase II/ Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics Doses First Patient in an Open Label Basket Study of SLS-005 in Amyotrophic Lateral Sclero...

    Details : SLS-005 (trehalose injection), is low molecular weight disaccharide that crosses BBB and is thought to stabilize proteins and activate autophagy through activation of Transcription Factor EB, a key factor in lysosomal and autophagy gene expression.

    Product Name : SLS-005

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    July 18, 2022

    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Highest Development Status : Phase II/ Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics

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    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Study Phase : IND Enabling

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Seelos Therapeutics Receives an Acknowledgement Letter of a Clinical Trial Notification from the Australian Go...

    Details : SLS-005 is a low molecular weight disaccharide (0.342 kDa) that crosses the blood brain barrier and is thought to stabilize proteins and activate autophagy through the activation of Transcription Factor EB (TFEB), a key factor in lysosomal and autophagy ...

    Product Name : SLS-005

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    March 08, 2022

    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Highest Development Status : IND Enabling

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics

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    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Study Phase : Phase II

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Seelos Therapeutics to Present at the 4th Annual ALS ONE Research Symposium

    Details : In in-vivo studies of ALS, trehalose has been shown to increase the clearance of TDP-43, decrease SOD1 and SQSM1/p62 aggregates and monomers, delay the progression of the disease, preserve ventral horn motor neurons and increase muscle fiber size.

    Product Name : SLS-005

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    November 10, 2021

    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Highest Development Status : Phase II

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics

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    Lead Product(s) : Trehalose API

    Therapeutic Area : Genetic Disease

    Study Phase : Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Seelos Therapeutics Receives European Orphan Drug Designation for SLS-005 (Trehalose) in Amyotrophic Lateral S...

    Details : SLS-005 (Trehalose) is a low molecular weight disaccharide (0.342 kDa) that crosses the blood brain barrier, stabilizes proteins and, importantly, activates autophagy used for treatment of amyotrophic lateral sclerosis (ALS).

    Product Name : SLS-005

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    May 27, 2021

    Lead Product(s) : Trehalose API

    Therapeutic Area : Genetic Disease

    Highest Development Status : Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics

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    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Study Phase : Phase II

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

    DEALS_DEV arrow-down

    Seelos Therapeutics Receives Positive EMA Opinion on Orphan Drug Designation for SLS-005 (Trehalose) in Amyotr...

    Details : Seelos Therapeutics has received a positive opinion on European Orphan Drug Designation for SLS-005 in amyotrophic lateral sclerosis (ALS) from the European Medicines Agency (EMA) Committee for Orphan Medicinal Products (COMP).

    Product Name : SLS-005

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    April 20, 2021

    Lead Product(s) : Trehalose API

    Therapeutic Area : Neurology

    Highest Development Status : Phase II

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Johnson & Johnson Innovative Medicine

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    Lead Product(s) : Miglustat,Trehalose API

    Therapeutic Area : Genetic Disease

    Study Phase : Preclinical

    Sponsor : Beyond Batten Disease Foundation

    Deal Size : Undisclosed

    Deal Type : Collaboration

    DEALS_DEV arrow-down

    Beyond Batten Disease Foundation Announces Agreement with Actelion Pharmaceuticals Ltd to Provide Drug Product...

    Details : Janssen will provide drug supply for the clinical trials and Extended Access Program, and right of reference to data within the Zavesca New Drug Application (NDA) to support the development of BBDF-101.

    Product Name : BBDF 101

    Product Type : Small molecule

    Upfront Cash : Undisclosed

    March 02, 2021

    Lead Product(s) : Miglustat,Trehalose API

    Therapeutic Area : Genetic Disease

    Highest Development Status : Preclinical

    Sponsor : Beyond Batten Disease Foundation

    Deal Size : Undisclosed

    Deal Type : Collaboration

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    Seelos Therapeutics

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    Lead Product(s) : Trehalose API

    Therapeutic Area : Genetic Disease

    Study Phase : Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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    Seelos Therapeutics Receives a Notice of Allowance in Japan for SLS-005 (Trehalose)

    Details : Seelos Therapeutics has received a Notice of Allowance from the Japanese Patent Office covering SLS-005 titled: "Treatment of Protein Aggregation Myopathic and Neurodegenerative Diseases by Parenteral Administration of Trehalose".

    Product Name : SLS-005

    Product Type : Small molecule

    Upfront Cash : Not Applicable

    January 22, 2021

    Lead Product(s) : Trehalose API

    Therapeutic Area : Genetic Disease

    Highest Development Status : Phase III

    Sponsor : Not Applicable

    Deal Size : Not Applicable

    Deal Type : Not Applicable

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