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    [{"orgOrder":0,"company":"Orphalan","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Trientine Tetrahydrochloride","moa":"Copper","graph1":"Genetic Disease","graph2":"Approved","graph3":"Orphalan","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Orphalan \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Orphalan \/ Not Applicable"},{"orgOrder":0,"company":"Orphalan","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Trientine Tetrahydrochloride","moa":"Copper","graph1":"Genetic Disease","graph2":"Approved","graph3":"Orphalan","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Tablet, Film Coated","sponsorNew":"Orphalan \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Orphalan \/ Not Applicable"},{"orgOrder":0,"company":"Orphalan","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2022","type":"Not Applicable","leadProduct":"Trientine Tetrahydrochloride","moa":"Copper","graph1":"Genetic Disease","graph2":"Approved","graph3":"Orphalan","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Orphalan \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Orphalan \/ Not Applicable"},{"orgOrder":0,"company":"Orphalan","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2023","type":"Not Applicable","leadProduct":"Trientine Tetrahydrochloride","moa":"","graph1":"Genetic Disease","graph2":"Approved","graph3":"Orphalan","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Tablet, Film Coated","sponsorNew":"Orphalan \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Orphalan \/ Not Applicable"},{"orgOrder":0,"company":"Orphalan","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2024","type":"Not Applicable","leadProduct":"Trientine Tetrahydrochloride","moa":"","graph1":"Genetic Disease","graph2":"Approved","graph3":"Orphalan","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Tablet, Film Coated","sponsorNew":"Orphalan \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Orphalan \/ Not Applicable"}]

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    Trientine Tetrahydrochloride

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                            01

                            Orphalan

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                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Orphalan Announces China Approval for Trientine Tetrahydrochloride Product

                            Details : Cuprior (trientine tetrahydrochloride) is a copper chelator that removes absorbed copper from the body by forming a stable complex eliminated through urine, for treating Wilson disease.

                            Brand Name : Cuprior

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 18, 2024

                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            02

                            Orphalan

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                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Orphalan Announces US Commercial Launch of Cuvrior™ for the Treatment of Wilson Disease

                            Details : Cuvrior (trientine hydrochloride) is a copper chelator that forms a complex with absorbed copper and then gets eliminated through urinary excretion. It is available in US for the treatment of stable Wilson disease who are de-coppered and tolerant to peni...

                            Brand Name : Cuvrior

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            April 20, 2023

                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            03

                            Orphalan

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                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Orphalan Announces Publication of Results from the CHELATE Trial in The Lancet Gastroenterology & Hepatology

                            Details : Using this NCC measurement Cuvrior (trientine tetrahydrochloride) was determined to be non-inferior to penicillamine at primary endpoint of study (24 weeks), with same observation at end of extension phase of study in patients receiving maintenance penic...

                            Brand Name : Cuvrior

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            September 30, 2022

                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Orphalan

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                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Orphalan Announces Data From Secondary Analyses of the CHELATE Trial for Maintenance Patients With Wilson’s ...

                            Details : Cuvrior™ (trientine tetrahydrochloride) is an oral trientine formulation. In the U.S., trientine tetrahydrochloride has been granted Orphan Drug Designation for the treatment of Wilson’s disease.

                            Brand Name : Cuvrior

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 22, 2022

                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Orphalan

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                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Orphalan Announces FD Approval of Cuvrior™ for the Treatment of Adult Patients With Stable Wilson’s Diseas...

                            Details : Orphalan recently completed a global phase III trial, CHELATE, which met its primary efficacy endpoint by demonstrating that Cuvrior, a new salt of trientine (trientine tetrahydrochloride) was non-inferior to penicillamine as measured by non-ceruloplasmi...

                            Brand Name : Cuvrior

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            May 02, 2022

                            Lead Product(s) : Trientine Tetrahydrochloride

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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