Lead Product(s) : Troriluzole
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Biohaven Reports Positive Results for Troriluzole in Spinocerebellar Ataxia
Details : BHV-4157 (troriluzole ) is a third-generation novel prodrug that modulates glutamate, the most abundant excitatory neurotransmitter in the human body. It is being evaluated for Spinocerebellar Ataxia.
Brand Name : BHV-4157
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 23, 2024
Lead Product(s) : Troriluzole
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Troriluzole
Therapeutic Area : Genetic Disease
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Troriluzole (BHV-4157) is a third-generation prodrug and new chemical entity that modulates glutamate, the most abundant excitatory neurotransmitter in the human body. The primary mode of action of troriluzole is reducing synaptic levels of glutamate.
Brand Name : BHV-4157
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 23, 2022
Lead Product(s) : Troriluzole
Therapeutic Area : Genetic Disease
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Troriluzole
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
BioShin Gets China NMPA Nod to Begin Clinical Trial of New Glutamate Modulator
Details : Troriluzole increases glutamate uptake from the synapse, by augmenting the expression and function of excitatory amino acid transporters located on glial cells that play a key role in clearing glutamate from the synapse, in order to reducing synaptic lev...
Brand Name : BHV4157
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 06, 2021
Lead Product(s) : Troriluzole
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Troriluzole
Therapeutic Area : Neurology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Biohaven Provides Update On Phase 2/3 Trial And Alzheimer's Disease Program
Details : Troriluzole did not statistically differentiate from placebo at 48 weeks on the study's prespecified co-primary endpoints on the Alzheimer's Disease Assessment Scale-Cognitive Subscale 11 and the Clinical Dementia Rating Scale Sum of Boxes.
Brand Name : BHV-4157
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 18, 2021
Lead Product(s) : Troriluzole
Therapeutic Area : Neurology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Troriluzole
Therapeutic Area : Neurology
Study Phase : Phase III
Sponsor : Biohaven Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Partnership
Details : Biohaven Pharmaceuticals, the first industry sponsor of the Collaborative, is currently conducting a Phase 3 clinical trial of troriluzole for Spinocerebellar Ataxia (SCA).
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Undisclosed
November 11, 2020
Lead Product(s) : Troriluzole
Therapeutic Area : Neurology
Highest Development Status : Phase III
Sponsor : Biohaven Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Partnership
Lead Product(s) : Troriluzole
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Biohaven Announces OCD Proof Of Concept Phase 2/3 Study
Details : Troriluzole 200 mg administered once daily as adjunctive therapy in OCD patients with inadequate response to standard of care treatment showed consistent numerical improvement over placebo on the Yale-Brown Obsessive Compulsive Scale at all study timepoi...
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 24, 2020
Lead Product(s) : Troriluzole
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase II/ Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Troriluzole
Therapeutic Area : Psychiatry/Psychology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Biohaven anxiety treatment fails late-stage study, shares fall 16%
Details : In the study, patients receiving the experimental drug, troriluzole, twice everyday did not show improvement in anxiety symptoms, compared to a placebo.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 10, 2020
Lead Product(s) : Troriluzole
Therapeutic Area : Psychiatry/Psychology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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