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Applicable"},{"orgOrder":0,"company":"TScan Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2022","type":"Not Applicable","leadProduct":"TSC-101","moa":"","graph1":"Oncology","graph2":"Phase I","graph3":"TScan Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"TScan Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"TScan Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"TScan Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"","productType":"Cell and Gene therapy","year":"2022","type":"Not Applicable","leadProduct":"TSC-203","moa":"","graph1":"Oncology","graph2":"IND Enabling","graph3":"TScan 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\/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"TScan Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"TScan Therapeutics","sponsor":"Amgen Inc","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"","productType":"Undisclosed","year":"2023","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Gastroenterology","graph2":"Discovery","graph3":"TScan Therapeutics","amount2":0.53000000000000003,"highestDevelopmentShortName":"Discovery","therapeuticAreaShortName":"Gastroenterology","amount2New":0.53000000000000003,"dosageForm":"","sponsorNew":"TScan Therapeutics \/ Amgen Inc","highestDevelopmentStatusID":"2","companyTruncated":"TScan Therapeutics \/ Amgen Inc"},{"orgOrder":0,"company":"TScan Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Infections and Infectious Diseases","country":"","productType":"Cell and Gene therapy","year":"2023","type":"Not 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Find Clinical Drug Pipeline Developments & Deals by TScan Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TSC-100 is an engineered T-cell receptor therapy, being evaluated for the patients with acute myeloid leukemia, acute lymphoblastic leukemia & myelodysplastic syndrome.

                          Brand Name : TSC-100

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 29, 2024

                          Lead Product(s) : TSC-100

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          02

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The company’s lead TCR-T candidate, TSC-203-A0201, is in clinical development for the treatment of patients with head and neck cancer and cervical cancer.

                          Brand Name : TSC-203-A0201

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          May 09, 2024

                          Lead Product(s) : TSC-203-A0201

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TSC-203-A0201 is TScan’s fourth TCR-T cell product cleared IND for use in its solid tumor program, designed to enable customized, multiplexed TCR-T cell therapy.

                          Brand Name : TSC-203-A0201

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          August 29, 2023

                          Lead Product(s) : TSC-203-A0201

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TSC-200-A0201, a TCR-T targeting human papillomavirus 16 (HPV16) and the third TCR cleared for clinical development in the Company’s ImmunoBank following TSC-204-A0201 and TSC-204-C0702, which target MAGE-A1 presented on HLA types A*02:01 and C*07:02, ...

                          Brand Name : TSC-200-A0201

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          June 06, 2023

                          Lead Product(s) : TSC-200-A0201

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : Under the terms of agreement, Amgen will evaluate a variety of modalities to create therapeutics based on targets discovered by TScan's proprietary target discovery platform, TargetScan, to identify the antigens recognized by T cells in patients with Cro...

                          Brand Name : Undisclosed

                          Molecule Type : Undisclosed

                          Upfront Cash : $30.0 million

                          May 09, 2023

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Discovery

                          Sponsor : Amgen Inc

                          Deal Size : $530.0 million

                          Deal Type : Collaboration

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                          06

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TSC-101 targets MiHA, HA-1 and HA-2, respectively, to treat residual leukemia and prevent relapse following hematopoietic cell transplantation using reduced intensity conditioning for acute myeloid leukemia, myelodysplastic syndromes or acute lymphocytic...

                          Brand Name : TSC-101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          March 14, 2023

                          Lead Product(s) : TSC-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TSC-204-A0201 targets melanomaassociated antigen 1 (MAGE-A1) on HLA types A*02 and C*07. MAGE-A1 is a cancer-associated antigen overexpressed in 45% of head and neck cancers and 50% of melanoma, cervical, and non-small cell lung cancers.

                          Brand Name : TSC-204-A0201

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          January 23, 2023

                          Lead Product(s) : TSC-204-A0201

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TSC-100 and TSC-101, are in development for the treatment of patients with hematologic malignancies to eliminate residual disease and prevent relapse after allogeneic hematopoietic cell transplantation.

                          Brand Name : TSC-101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          December 12, 2022

                          Lead Product(s) : TSC-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : The first four product candidates include a combination of known targets, such as HPV16 for TSC-200 and PRAME for TSC-203, as well as novel targets for TCR-T therapy, such as TSC-201 and TSC-202.

                          Brand Name : TSC-203

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 11, 2022

                          Lead Product(s) : TSC-203

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          10

                          2024 ACI Convention
                          Not Confirmed
                          2024 ACI Convention
                          Not Confirmed

                          Details : TSC-100 and TSC-101, are designed to target HA-1 and HA-2, respectively, to prevent relapse in AML, ALL and MDS patients undergoing allogeneic haploidentical hematopoietic cell transplantation (HCT) with reduced intensity conditioning (RIC).

                          Brand Name : TSC-101

                          Molecule Type : Cell and Gene therapy

                          Upfront Cash : Not Applicable

                          November 03, 2022

                          Lead Product(s) : TSC-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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