Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Tucatinib,Trastuzumab Emtansine
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TUKYSA (tucatinib) is an oral medicine that is a tyrosine kinase inhibitor of the HER2 protein and in combination with ado-trastuzumab emtansine is being developed in patients with HER2-positive metastatic or unresectable breast cancer.
Brand Name : Tukysa
Molecule Type : Small molecule
Upfront Cash : Not Applicable
December 06, 2023
Lead Product(s) : Tucatinib,Trastuzumab Emtansine
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TUKYSA (tucatinib) is an oral medicine that is a tyrosine kinase inhibitor of the HER2 protein and in combination with ado-trastuzumab emtansine is being developed in patients with HER2-positive metastatic or unresectable breast cancer.
Brand Name : Tukysa
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 16, 2023
Lead Product(s) : Tucatinib,Trastuzumab
Therapeutic Area : Oncology
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Tukysa (tucatinib) is a TKI of HER2, inhibiting phosphorylation of HER2 and HER3, resulting in inhibition of downstream MAPK and AKT signaling and cell proliferation, and showed antitumor activity in HER2 expressing tumor cells in combination with trastu...
Brand Name : Tukysa
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 19, 2023
Lead Product(s) : Tucatinib,Trastuzumab
Therapeutic Area : Oncology
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tucatinib,Trastuzumab,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : In vivo (in living organisms), TUKYSA (tucatinib) inhibited the growth of HER2-expressing tumors. The combination of TUKYSA and the anti-HER2 antibody trastuzumab showed increased anti-tumor activity in vitro and in vivo compared to either medicine alone...
Brand Name : Tuksya
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 19, 2022
Lead Product(s) : Tucatinib,Trastuzumab,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tucatinib,Trastuzumab,Oxaliplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Merck & Co
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : At a median duration of follow-up of 20.7 months, results of MOUNTAINEER trial showed a 38.1% cORR per blinded independent central review in HER2-positive patients who were assigned to receive Tuksya (tucatinib) in combination with trastuzumab.
Brand Name : Tuksya
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 02, 2022
Lead Product(s) : Tucatinib,Trastuzumab,Oxaliplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Merck & Co
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Tucatinib,Capecitabine,Trastuzumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Seagen to Highlight New Data in Advanced Breast Cancer at 2021 San Antonio Breast Cancer Symposium
Details : Pivotal HER2CLIMB trial showed that TUKYSA resulted in a robust and durable prolongation of overall survival that was consistent with results from the primary analysis for HER2-positive metastatic breast cancer patients with brain metastases.
Brand Name : Tukysa
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 19, 2021
Lead Product(s) : Tucatinib,Capecitabine,Trastuzumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Zanidatamab,Tucatinib,Capecitabine
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Zanidatamab is a bispecific antibody, based on Zymeworks’ Azymetric™ platform. Zymeworks is developing zanidatamab in multiple Phase 1, Phase 2, and pivotal clinical trials globally as a targeted treatment option for patients with solid tumors that e...
Brand Name : ZW25
Molecule Type : Large molecule
Upfront Cash : Not Applicable
November 19, 2021
Lead Product(s) : Zanidatamab,Tucatinib,Capecitabine
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Zanidatamab,Tucatinib,Capecitabine
Therapeutic Area : Oncology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
First Patient with HER2-Ve+ Breast Cancer Dosed with Zanidatamab Tukysa Combo
Details : Zanidatamab binds to HER2 across a range of expression levels and has demonstrated multiple mechanisms of action including the formation of receptor clusters, resulting in receptor internalization and downregulation that affect signal transduction .
Brand Name : ZW25
Molecule Type : Large molecule
Upfront Cash : Not Applicable
July 28, 2021
Lead Product(s) : Zanidatamab,Tucatinib,Capecitabine
Therapeutic Area : Oncology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Cinrebafusp alfa,Tucatinib
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Pieris Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Pieris' option to co-develop and co-commercialize the second of 3 programs in the collaboration has been amended to provide it with a co-promotion option in the U.S, with Seagen solely responsible for the development and overall commercialization of that...
Brand Name : PRS-343
Molecule Type : Large molecule
Upfront Cash : Undisclosed
March 25, 2021
Lead Product(s) : Cinrebafusp alfa,Tucatinib
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Pieris Pharmaceuticals
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Patients who received TUKYSA in combination with trastuzumab and capecitabine in the pivotal trial had a 46 percent reduction in the risk of cancer progression or death compared to patients who received trastuzumab and capecitabine alone.
Brand Name : Tukysa
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 12, 2021
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