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Find Clinical Drug Pipeline Developments & Deals by Tvardi Therapeutics

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : Tvardi will merge with Cara, combining resources and expertise in STAT3 inhibition, including its mid-stage lead program, TTI-101, for the treatment of idiopathic pulmonary fibrosis.

                          Product Name : Undisclosed

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          December 18, 2024

                          Lead Product(s) : TTI-101

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : CARA Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Merger

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                          02

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : TTI-101, an orally delivered, small molecule, direct inhibitor of STAT3, is being developed alone or in combination with nintedanib in phase 2 trial in patients with idiopathic pulmonary fibrosis.

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          August 31, 2023

                          Lead Product(s) : TTI-101

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          03

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : TTI-101, an orally delivered, small molecule, direct inhibitor of STAT3, is being developed in phase 3 trial in patients with locally advanced or metastatic, and unresectable hepatocellular carcinoma (HCC).

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          June 22, 2023

                          Lead Product(s) : TTI-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          04

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : TTI-101 is an orally bioavailable, small-molecule inhibitor of signal transducer and activator of transcription 3, a transcription factor whose upregulation and activation governs many hallmarks of cancer, inflammation, and fibrosis.

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          February 23, 2023

                          Lead Product(s) : TTI-101,Palbociclib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          05

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : TTI-101 is an orally delivered, small molecule, direct inhibitor of STAT3. STAT3 is a key regulatory protein which plays a critical role in the pathogenesis of HCC by initiating tumorigenesis as well as promoting an immunosuppressive tumor microenvironme...

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          October 19, 2022

                          Lead Product(s) : TTI-101,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          06

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : TTI-101 is an orally-delivered, small molecule, direct STAT3 inhibitor. STAT3 has emerged as a central node of fibrosis and has been found to accumulate in the fibrotic lungs of IPF patients.

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          May 26, 2022

                          Lead Product(s) : TTI-101

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : IND Enabling

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          07

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : TTI-101 is an orally delivered, small molecule, direct inhibitor of STAT3. STAT3 is a key regulatory protein which plays a critical role in the pathogenesis of HCC by initiating tumorigenesis as well as promoting an immunosuppressive tumor microenvironme...

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 21, 2022

                          Lead Product(s) : TTI-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : Studies demonstrated that combination of TTI-101 with palbociclib is synergistic in arresting tumor growth in murine models derived from metastatic breast cancer patients who had developed resistance to palbociclib.

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Not Applicable

                          April 07, 2022

                          Lead Product(s) : TTI-101,Palbociclib

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          09

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : The company’s lead product, TTI-101, is currently being studied in a Phase 1 trial of patients with advanced solid tumors who have failed all lines of therapy.

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 27, 2021

                          Lead Product(s) : TTI-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Slate Path Capital

                          Deal Size : $74.0 million

                          Deal Type : Series B Financing

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                          10

                          RNA Therapeutics
                          Not Confirmed
                          RNA Therapeutics
                          Not Confirmed

                          Details : Funding to support clinical trials of TTI-101 in hepatocellular carcinoma and gastrointestinal cancer as well as funding from the PREVENT program to support translational work of TTI-101 in HCC prevention.

                          Product Name : TTI-101

                          Product Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 24, 2020

                          Lead Product(s) : TTI-101

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : National Cancer Institute

                          Deal Size : $5.0 million

                          Deal Type : Funding

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