[{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Secura Bio","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2020","type":"Divestment","leadProduct":"Duvelisib","moa":"PI3K delta\/gamma","graph1":"Oncology","graph2":"Approved FDF","graph3":"Verastem Oncology","amount2":0,"highestDevelopmentShortName":"","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Verastem Oncology \/ Secura Bio","highestDevelopmentStatusID":"15","companyTruncated":"Verastem Oncology \/ Secura Bio"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Secura Bio","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2020","type":"Divestment","leadProduct":"Duvelisib","moa":"PI3K delta\/gamma","graph1":"Oncology","graph2":"Approved FDF","graph3":"Verastem 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Inc","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Collaboration","leadProduct":"Avutometinib","moa":"||RAF\/MEK","graph1":"Oncology","graph2":"Phase II","graph3":"Verastem Oncology","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Verastem Oncology \/ Amgen Inc","highestDevelopmentStatusID":"8","companyTruncated":"Verastem Oncology \/ Amgen Inc"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Avutometinib","moa":"||RAF\/MEK","graph1":"Oncology","graph2":"Phase II","graph3":"Verastem Oncology","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Verastem Oncology \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Verastem Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"Avutometinib","moa":"||RAF\/MEK","graph1":"Oncology","graph2":"Phase II","graph3":"Verastem Oncology","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Verastem Oncology \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Verastem Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small 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Inapplicable","highestDevelopmentStatusID":"10","companyTruncated":"Verastem Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"RA Capital Management","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Private Placement","leadProduct":"Defactinib","moa":"||Focal adhesion kinase","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Verastem Oncology","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Verastem Oncology \/ RA Capital Management","highestDevelopmentStatusID":"7","companyTruncated":"Verastem Oncology \/ RA Capital Management"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small 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Therapeutics","highestDevelopmentStatusID":"2","companyTruncated":"Verastem Oncology \/ GenFleet Therapeutics"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2020","type":"Inapplicable","leadProduct":"Avutometinib","moa":"||RAF\/MEK","graph1":"Oncology","graph2":"Preclinical","graph3":"Verastem Oncology","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Capsule","sponsorNew":"Verastem Oncology \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Verastem Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"GFH375","moa":"KRAS G12D ON\/OFF","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Verastem Oncology","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Oral Tablet","sponsorNew":"Verastem Oncology \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Verastem Oncology \/ Inapplicable"},{"orgOrder":0,"company":"Verastem Oncology","sponsor":"RTW Investments","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Small Molecule","year":"2025","type":"Private Placement","leadProduct":"Avutometinib","moa":"||RAF\/MEK","graph1":"Oncology","graph2":"Phase III","graph3":"Verastem Oncology","amount2":0.080000000000000002,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Oncology","amount2New":0.080000000000000002,"dosageForm":"Oral Capsule","sponsorNew":"Verastem Oncology \/ RTW Investments","highestDevelopmentStatusID":"10","companyTruncated":"Verastem Oncology \/ RTW Investments"}]

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                          01

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The proceeds from the financing are expected to fund the potential launch of VS-6766 (avutometinib) and defactinib in recurrent low-grade serous ovarian cancer.

                          Product Name : VS-6766

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          April 25, 2025

                          Lead Product(s) : Avutometinib,Defactinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : RTW Investments

                          Deal Size : $75.0 million

                          Deal Type : Private Placement

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                          02

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : VS-7375 is an oral KRAS G12D (on/off) inhibitor, small molecule drug candidate, which is being evaluated for the treatment of advanced solid tumors.

                          Product Name : VS-7375

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 23, 2025

                          Lead Product(s) : GFH375

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The financing aims to advance the clinical development of company's lead product, VS-6766 (Avutometinib) plus defactinib. It is being evaluated for the KRAS mutant low-grade serous ovarian cancer.

                          Product Name : VS-6766

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          January 13, 2025

                          Lead Product(s) : Avutometinib,Defactinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Oberland Capital Management

                          Deal Size : $157.5 million

                          Deal Type : Financing

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                          04

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Combination of avutometinib, a RAF/MEK clamp, and defactinib, a selective FAK inhibitor, being development for adults with recurrent KRAS mutant low-grade serous ovarian cancer.

                          Product Name : VS-6766

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 30, 2024

                          Lead Product(s) : Avutometinib,Defactinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Combination of avutometinib, a RAF/MEK clamp with sotorasib & defactinib, , being developed for the treatment of KRAS G12C mutant non-small cell lung cancer.

                          Product Name : VS-6766

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 18, 2024

                          Lead Product(s) : Avutometinib,Defactinib,Sotorasib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The collaboration aims to support the advancement of the clinical development of VS-7375/GFH375 in china, which is being evaluated in the treatment of KRAS G12D-mutant solid tumors.

                          Product Name : VS-7375

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          December 07, 2024

                          Lead Product(s) : VS-7375

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : GenFleet Therapeutics

                          Deal Size : Undisclosed

                          Deal Type : Collaboration

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                          07

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Combination of avutometinib, a RAF/MEK clamp, and defactinib, a selective FAK inhibitor, being development for adults with recurrent KRAS mutant low-grade serous ovarian cancer.

                          Product Name : VS-6766

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 31, 2024

                          Lead Product(s) : Avutometinib,Defactinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Combination of avutometinib, a RAF/MEK clamp, and defactinib, a selective FAK inhibitor, being development for adult patients with pancreatic ductal adenocarcinoma.

                          Product Name : VS-6766

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 29, 2024

                          Lead Product(s) : Avutometinib,Defactinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The net proceeds from the public offering to fund the potential launch ofVS-6766 (avutometinib) and Defactinib in LGSOC & also continuing clinical research and development of other product candidates.

                          Product Name : VS-6766

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          July 23, 2024

                          Lead Product(s) : Avutometinib,Defactinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Guggenheim Securities

                          Deal Size : $55.0 million

                          Deal Type : Public Offering

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                          10

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Combination of avutometinib, a RAF/MEK clamp, and defactinib, a selective FAK inhibitor, being development for adult patients with recurrent KRAS mutant (KRAS mt) low-grade serous ovarian cancer.

                          Product Name : VS-6766

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          May 24, 2024

                          Lead Product(s) : Avutometinib,Defactinib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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