Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Buloxibutid
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vicore Reports Positive Results from Phase 2a AIR Trial of Buloxibutid in IPF
Details : C21 (buloxibutid) is an angiotensin II type 2 receptor agonist, which is currently being evaluated for the treatment of patients with idiopathic pulmonary fibrosis.
Brand Name : C21
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 20, 2024
Lead Product(s) : Buloxibutid
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Buloxibutid
Therapeutic Area : Endocrinology
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vicore Initiates Clinical Proof-Of-Concept Study of Endothelial Dysfunction
Details : C21 is an angiotensin II type 2 receptor agonist, which s being developed for the treatment endothelial dysfunction (reflecting blood vessel health) in patients with type-2-diabetes-mellitus.
Brand Name : C21
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 03, 2023
Lead Product(s) : Buloxibutid
Therapeutic Area : Endocrinology
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Buloxibutid
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vicore's Digital Therapeutic For IPF Patients Shows Nearly 50% Anxiety Reduction In Pilot Study
Details : C21 is a small molecule compound, which is in clinical development for the treatment of IPF and COVID-19. The experimental programme will assess the potential of C21 for addressing fibrosis, inflammation and vasculopathy in a variety of diseases such as ...
Brand Name : C21
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 06, 2022
Lead Product(s) : Buloxibutid
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VP01
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Orphan Reach
Deal Size : Not Applicable
Deal Type : Not Applicable
Vicore IPF Interim Data Selected as an Oral "Late-breaker" at the ERS Congress
Details : The AIR trial1 is an open label single arm phase 2 trial in treatment naïve IPF patients in which 100 mg of C21 (VP01) was administered twice daily for 24 weeks with an optional 12-week extension.
Brand Name : C21
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 17, 2022
Lead Product(s) : VP01
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Orphan Reach
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CAS 138564-60-0
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vicore announces first human dosed with novel ATRAG, C106
Details : C106 is first of four advanced candidate drugs from VP03 program to enter clinical trials. C106 and the three additional candidates are small molecules with high affinity for AT2R and intended for indications also outside rare lung disease.
Brand Name : C106
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 16, 2022
Lead Product(s) : CAS 138564-60-0
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase I
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : CAS 138564-60-0
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Preclinical
Sponsor : Emeriti Bio
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The first candidate in the VP03 program, new AT2R agonist C106, shows high selectivity for AT2R and good activity in reducing TGFb in human tissue with patent protection to 2041, is ready to enter a phase 1 trial.
Brand Name : VP03
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 23, 2022
Lead Product(s) : CAS 138564-60-0
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Preclinical
Sponsor : Emeriti Bio
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VP01
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vicore's AIR Study Interim Analysis Suggests that C21 Improves Lung Function in IPF Patients
Details : With these results, the company initiates the planning of AIR 2, a double-blind controlled phase 2 dose-finding study to confirm these results and accelerate the development of C21 in parallel to completing the AIR trial.
Brand Name : C21
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 10, 2022
Lead Product(s) : VP01
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VP01
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vicore’s C21 Reduces Long-Term Lung Injury After COVID-19 in the ATTRACT Phase 2 Extension Study
Details : The results showed nearly 50% reduction in lung injury in the C21 group compared with the placebo group suggest that C21 could accelerate recovery and it is currently being evaluated in a phase 3 trial in COVID-19 patients.
Brand Name : C21
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 02, 2021
Lead Product(s) : VP01
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VP01
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lancet's EClinicalMedicine Publishes Phase 2 Data On C21 in COVID-19
Details : C21 is a first-in-class, orally available, low molecular weight, angiotensin II type 2 receptor (AT2R) agonist that activates the “protective arm” of the renin-angiotensin system (RAS) leading to resolution and regeneration following tissue damage.
Brand Name : C21
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 25, 2021
Lead Product(s) : VP01
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : VP01
Therapeutic Area : Pulmonary/Respiratory Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Vicore Obtains SARS Coronavirus Patent for C21 in The USA
Details : C21 is first-in-class, orally available, low molecular weight, angiotensin II type 2 receptor agonist. C21 on respiratory function in COVID-19 was documented in recent phase 2 trial showing that C21 reduced need for supplemental oxygen in hospitalized pa...
Brand Name : C21
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 22, 2021
Lead Product(s) : VP01
Therapeutic Area : Pulmonary/Respiratory Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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