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Find Clinical Drug Pipeline Developments & Deals for Vidofludimus calcium anhydrous
The Company will fund the ongoing clinical development of its three lead candidates, IMU-838 (vidofludimus calcium), a small molecule investigational drug in development as an oral next generation treatment option for patients with multiple sclerosis, IMU-856 and IMU-381.
IMU-838 (vidofludimus calcium) is a small molecule investigational drug in development as an oral next-generation treatment option for patients with multiple sclerosis and other chronic inflammatory and autoimmune diseases.
IMU-838 (vidofludimus calcium) is a small molecule investigational drug in development as an oral next-generation treatment option for patients with multiple sclerosis and other chronic inflammatory and autoimmune diseases.
IMU-838 (vidofludimus calcium) inhibits dihydroorotate dehydrogenase (DHODH), a key enzyme for highly metabolically activated T and B immune cells experience metabolic stress, its inhibition results in less pro-inflammatory cytokines and thereby reduce the inflammation.
IMU-838 (vidofludimus calcium) is an investigational drug in development as an orally available, next-generation selective immune modulator that is designed to inhibit the intracellular metabolism of activated immune cells by blocking the enzyme DHODH.
The Company intends to use net proceeds from the financing to fund the ongoing clinical development of its three lead product candidates, vidofludimus calcium (IMU-838), IMU-935 and IMU-856, and for other general corporate purposes.
IMU-838 (Vidofludimus calcium) is an investigational drug in development as an orally available, next-generation selective immune modulator that is designed to inhibit the intracellular metabolism of activated immune cells by blocking the enzyme dihydroorotate dehydrogenase.
The trial did not achieve the primary endpoint of clinical remission for the pooled 30 and 45 mg/day active dose groups of IMU-838 (vidofludimus calcium) versus placebo at week 10.
IMU-838 is an orally available, next-generation selective immune modulator that inhibits the intracellular metabolism of activated immune cells by blocking the enzyme dihydroorotate dehydrogenase (DHODH) used in patients with progressive multiple sclerosis (PMS).
Preclinical research recently completed by Immunic and collaborators has shown that certain DHODH inhibitors, including it's lead asset, IMU-838, strongly synergize with selected nucleoside analogues to inhibit SARS-CoV-2 replication in vitro.
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