[{"orgOrder":0,"company":"Phathom Pharmaceuticals","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Vonoprazan Fumarate","moa":"P-CAB","graph1":"Gastroenterology","graph2":"Phase III","graph3":"Phathom Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph III","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Oral","sponsorNew":"Phathom Pharmaceuticals \/ Not Applicable","highestDevelopmentStatusID":"10","companyTruncated":"Phathom Pharmaceuticals \/ Not Applicable"},{"orgOrder":0,"company":"Takeda Pharmaceutical","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"","productType":"Small molecule","year":"2021","type":"Not Applicable","leadProduct":"Vonoprazan Fumarate","moa":"P-CAB","graph1":"Gastroenterology","graph2":"Phase III","graph3":"Takeda 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                          Top Deals by Deal Size (USD bn)

                          01

                          Details : Vonoprazan is a novel potassium-competitive acid blocker (PCAB). It inhibits gastric acid secretion by acting as a reversible competitive inhibitor against potassium ions.

                          Brand Name : Voquezna Triple Pack

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          October 24, 2022

                          Lead Product(s) : Vonoprazan Fumarate,Amoxicillin Trihydrate,Clarithromycin

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Approved

                          Sponsor : Phathom Pharmaceuticals

                          Deal Size : Undisclosed

                          Deal Type : Agreement

                          Evonik company banner

                          02

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Under the terms of this agreement, Takeda has granted Lupin non-exclusive patent licensing rights to commercialize Lupivon (vonoprazan), a novel potassium-competitive acid blocker, in India.

                          Brand Name : Lupivon

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 18, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Lupin Ltd

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          03

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : The licensing deal will enhance Alkem's offerings in the gastrointestinal segment by including Vonzai (vonoprazan), a first-in-class potassium-competitive acid blocker.

                          Brand Name : Vonzai

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          September 03, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Alkem Laboratories

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          04

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Phathom intends to use the net proceeds from the offering to fund commercialization expenses and further clinical development of Voquezna (vonoprazan) for the treatment of Erosive GERD.

                          Brand Name : Voquezna

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          August 19, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Evercore ISI

                          Deal Size : $130.0 million

                          Deal Type : Public Offering

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                          05

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Under the terms of this agreement, Takeda has granted Zydus non-exclusive patent licensing rights for the commercialization of Vault (vonoprazan) in India.

                          Brand Name : Vault

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 19, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status :

                          Sponsor : Zydus Lifesciences

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          06

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Under the terms of this agreement, Takeda has granted Reddy non-exclusive patent licensing rights for the commercialization of Voquezna (vonoprazan) in India.

                          Brand Name : Vault

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 19, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status :

                          Sponsor : Dr. Reddy\'s Laboratories

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          07

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Voquezna (vonoprazan) is an oral small molecule potassium-competitive acid blocker (PCAB). It is being developed for the treatment of heartburn due to Non-Erosive Gastroesophageal Reflux Disease.

                          Brand Name : Voquezna

                          Molecule Type : Small molecule

                          Upfront Cash : Not Applicable

                          July 18, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Not Applicable

                          Deal Size : Not Applicable

                          Deal Type : Not Applicable

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                          08

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Under the terms of this agreement, Takeda has granted Mankind Pharma non-exclusive patent licensing rights for the commercialization of Voquezna (vonoprazan) in India.

                          Brand Name : Voquezna

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          July 16, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status :

                          Sponsor : Mankind Pharma

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          09

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Under the terms of this agreement, Takeda has granted Sun Pharma non-exclusive patent licensing rights for the commercialization of Voltapraz (vonoprazan) in India.

                          Brand Name : Voltapraz

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 21, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Sun Pharmaceutical Industries Limited

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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                          10

                          Medlab Asia & Asia Health
                          Not Confirmed
                          Medlab Asia & Asia Health
                          Not Confirmed

                          Details : Under the terms of this agreement, Takeda has granted Cipla non-exclusive patent licensing rights for the commercialization of Voltapraz (vonoprazan) in India.

                          Brand Name : Voltapraz

                          Molecule Type : Small molecule

                          Upfront Cash : Undisclosed

                          June 20, 2024

                          Lead Product(s) : Vonoprazan Fumarate

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Approved

                          Sponsor : Cipla

                          Deal Size : Undisclosed

                          Deal Type : Licensing Agreement

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