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    [{"orgOrder":0,"company":"Global Blood Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Voxelotor","moa":"HbA positive","graph1":"Hematology","graph2":"Approved","graph3":"Global Blood Therapeutics","amount2":0,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Hematology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Global Blood Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"12","companyTruncated":"Global Blood Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Global Blood Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2020","type":"Not Applicable","leadProduct":"Voxelotor","moa":"HbA positive","graph1":"Hematology","graph2":"Approved","graph3":"Global Blood 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Therapeutics","sponsor":"Pfizer Inc","pharmaFlowCategory":"D","therapeuticArea":"Genetic Disease","country":"","productType":"Small molecule","year":"2022","type":"Acquisition","leadProduct":"Voxelotor","moa":"HbA positive","graph1":"Hematology","graph2":"Approved","graph3":"Global Blood Therapeutics","amount2":5.4000000000000004,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Hematology","amount2New":5.4000000000000004,"dosageForm":"Tablet","sponsorNew":"Global Blood Therapeutics \/ Pfizer","highestDevelopmentStatusID":"12","companyTruncated":"Global Blood Therapeutics \/ Pfizer"},{"orgOrder":0,"company":"Global Blood Therapeutics","sponsor":"Pfizer Inc","pharmaFlowCategory":"D","therapeuticArea":"Hematology","country":"U.S.A","productType":"Small molecule","year":"2022","type":"Acquisition","leadProduct":"Voxelotor","moa":"HbA positive","graph1":"Hematology","graph2":"Approved","graph3":"Global Blood Therapeutics","amount2":5.4000000000000004,"highestDevelopmentShortName":"Approved","therapeuticAreaShortName":"Hematology","amount2New":5.4000000000000004,"dosageForm":"Tablet","sponsorNew":"Global Blood Therapeutics \/ Pfizer Inc","highestDevelopmentStatusID":"12","companyTruncated":"Global Blood Therapeutics \/ Pfizer Inc"}]

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                            01

                            Global Blood Therapeutics

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                            Fi Europe 2024
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                            Global Blood Therapeutics

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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Pfizer Inc

                            Deal Size : $5,400.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Pfizer Completes Acquisition of Global Blood Therapeutics

                            Details : Acquisition brings leading sickle cell disease portfolio and pipeline including Oxbryta® (voxelotor), a first-in-class medicine that directly targets the root cause of SCD, to Pfizer with potential to address critical needs in an underserved patient com...

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : $5,400.0 million

                            October 05, 2022

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Pfizer Inc

                            Deal Size : $5,400.0 million

                            Deal Type : Acquisition

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                            02

                            Global Blood Therapeutics

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                            Fi Europe 2024
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                            Global Blood Therapeutics

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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Hematology

                            Study Phase : Approved

                            Sponsor : Pfizer Inc

                            Deal Size : $5,400.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Pfizer to Acquire Global Blood Therapeutics for $5.4 Billion to Enhance Presence in Rare Hematology

                            Details : Proposed acquisition drives growth by bringing leading sickle cell disease expertise and rare hematology portfolio and pipeline of GBT including Oxbryta (voxelotor) tablets for treatment of sickle cell disease (SCD) and GBT601.

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : $5,400.0 million

                            August 08, 2022

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Hematology

                            Highest Development Status : Approved

                            Sponsor : Pfizer Inc

                            Deal Size : $5,400.0 million

                            Deal Type : Acquisition

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                            03

                            Global Blood Therapeutics

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                            Global Blood Therapeutics

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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            GBT Initiates Expanded Access Program for Voxelotor in Patients With Sickle Cell Disease in Brazil

                            Details : Oxbryta (Voxelotor) works by increasing hemoglobin’s affinity for oxygen, inhibits sickle hemoglobin polymerization and resultant sickling and destruction of red blood cells leading to hemolysis and anemia, are primary pathologies faced by every single...

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            July 14, 2022

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Global Blood Therapeutics

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                            Fi Europe 2024
                            Not Confirmed

                            Global Blood Therapeutics

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                            Fi Europe 2024
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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            GBT Presents Positive New Real-World Evidence Data at EHA2022 Congress Further Supporting Clinical Use of Oxbr...

                            Details : Oxbryta (voxelotor) is an oral, once-daily therapy for patients with sickle cell disease (SCD). Oxbryta works by increasing hemoglobin’s affinity for oxygen.

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            June 10, 2022

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            05

                            Global Blood Therapeutics

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                            Fi Europe 2024
                            Not Confirmed

                            Global Blood Therapeutics

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                            Fi Europe 2024
                            Not Confirmed
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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            European Medicines Agency Approves OXBRYTA® (voxelotor), First Treatment Approved in the EU to Target the Cau...

                            Details : The first sickle hemoglobin polymerization inhibitor approved in Europe, Oxbryta increases hemoglobin levels and reduces sickling and hemolysis – the cause of long-term complications of sickle cell disease.

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            February 16, 2022

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Global Blood Therapeutics

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                            Fi Europe 2024
                            Not Confirmed

                            Global Blood Therapeutics

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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Positive Early Access to Medicines Scheme (EAMS) Scientific Opinion Awarded to GBT’s Voxelotor for the Treat...

                            Details : This positive opinion means that those patients living with SCD and meeting the eligibility criteria can gain early, pre-license access to voxelotor, while the MHRA completes its review of the Marketing Authorisation Application (MAA).

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            January 27, 2022

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Global Blood Therapeutics

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                            Fi Europe 2024
                            Not Confirmed

                            Global Blood Therapeutics

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                            Fi Europe 2024
                            Not Confirmed
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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            U.S. FDA Approves Supplemental New Drug Application for Expanded Indication of Oxbryta® (Voxelotor) for Child...

                            Details : The FDA’s approval of the sNDA is based on data from the open-label Phase 2a HOPE-KIDS 1 Study, which showed that weight-based treatment with the dispersible tablet formulation of Oxbryta (Voxelotor) resulted in rapid and sustained improvements in hemo...

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 17, 2021

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Global Blood Therapeutics

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                            Fi Europe 2024
                            Not Confirmed

                            Global Blood Therapeutics

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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            GBT’s Oxbryta® (voxelotor) Receives Positive CHMP Opinion for the Treatment of Hemolytic Anemia in Patients...

                            Details : CHMP opinion is based on Phase 3 HOPE study which demonstrated clinically meaningful and statistically significant improvements in Hb levels and reductions in hemolysis, for patients treated with Oxbryta (Voxelotor) as monotherapy or in combination with ...

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            December 17, 2021

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Global Blood Therapeutics

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                            Global Blood Therapeutics

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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Undisclosed

                            Deal Size : $300.0 million

                            Deal Type : Public Offering

                            DEALS_DEV arrow-down

                            GBT Announces Pricing of Upsized Offering of $300.0 Million of Convertible Senior Notes

                            Details : GBT intends to use the remainder of the net proceeds from the offering for the continued commercialization of Oxbryta® (voxelotor) and the clinical development of Oxbryta® and GBT’s product candidates.

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : Undisclosed

                            December 15, 2021

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Undisclosed

                            Deal Size : $300.0 million

                            Deal Type : Public Offering

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                            10

                            Global Blood Therapeutics

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                            Fi Europe 2024
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                            Global Blood Therapeutics

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                            Fi Europe 2024
                            Not Confirmed
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                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Study Phase : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            GBT Wins Prestigious Prix Galien USA Award for Oxbryta® (voxelotor)

                            Details : An oral, once-daily therapy, Oxbryta directly inhibits hemoglobin polymerization, the root cause of the sickling and destruction of red blood cells in SCD. The sickling process causes hemolytic anemia, which impairs oxygen delivery to the tissues and org...

                            Brand Name : Oxbryta

                            Molecule Type : Small molecule

                            Upfront Cash : Not Applicable

                            November 01, 2021

                            Lead Product(s) : Voxelotor

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Approved

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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