Lead Product(s) : Xevinapant,Cisplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Merck Provides Update on Phase III TrilynX Study in Locally Advanced Head and Neck Cancer
Details : Debio 1143 (xevinapant) is an investigational potent oral small-molecule IAP inhibitor. It is being evaluated for the treatment of locally advanced squamous cell carcinoma of the head and neck.
Brand Name : Debio 1143
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 24, 2024
Lead Product(s) : Xevinapant,Cisplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Xevinapant
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Merck Group
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Xevinapant (formerly known as Debio 1143) is an investigational first-in-class potent oral small-molecule IAP (inhibitor of apoptosis protein) inhibitor for the treatment of LA SCCHN.
Brand Name : Debio 1143
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 07, 2022
Lead Product(s) : Xevinapant
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Merck Group
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Xevinapant,Cisplatin
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Merck Group
Deal Size : $1,070.0 million
Deal Type : Collaboration
Details : Xevinapant is the first Inhibitor of Apoptosis Proteins antagonist with FDA Breakthrough Therapy Designation for previously untreated locally advanced squamous cell carcinoma of the head and neck, in combination with current standard of care.
Brand Name : Debio 1143
Molecule Type : Small molecule
Upfront Cash : $224.4 million
March 01, 2021
Lead Product(s) : Xevinapant,Cisplatin
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Merck Group
Deal Size : $1,070.0 million
Deal Type : Collaboration
Lead Product(s) : Xevinapant,Cisplatin,Radiotherapy
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The clinical trial is being conducted to demonstrate the superior efficacy of xevinapant vs. placebo when added to CRT in high risk head and neck patients including those affected in the throat and vocal chords (oropharynx -HPV-negative, hypopharynx and ...
Brand Name : Debio 1143
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 01, 2020
Lead Product(s) : Xevinapant,Cisplatin,Radiotherapy
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Xevinapant,Cisplatin,Radiotherapy
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The virtual late breaking abstract presentation of the 3-year update for the xevinapant phase II study in high-risk previously untreated locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN) patients, will be Presented at ESMO Virtual ...
Brand Name : Debio 1143
Molecule Type : Small molecule
Upfront Cash : Not Applicable
September 17, 2020
Lead Product(s) : Xevinapant,Cisplatin,Radiotherapy
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Xevinapant,Cisplatin,Radiotherapy
Therapeutic Area : Oncology
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Debio 1143 with CRT showed a statistically and clinically significant improvement in Overall Survival (OS) vs. the control group, suggesting a halving of the risk of mortality.
Brand Name : Debio 1143
Molecule Type : Small molecule
Upfront Cash : Not Applicable
August 13, 2020
Lead Product(s) : Xevinapant,Cisplatin,Radiotherapy
Therapeutic Area : Oncology
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Xevinapant,Cisplatin
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
FDA Grants Breakthrough Therapy Designation for Debiopharm's Novel Chemo-Radio Sensitizer Debio 1143
Details : The FDA decision was based on the compelling magnitude of the clinically phase II findings in combination with chemo-radiotherapy presented in September 2019 at the ESMO congress.
Brand Name : Undisclosed
Molecule Type : Small molecule
Upfront Cash : Not Applicable
February 27, 2020
Lead Product(s) : Xevinapant,Cisplatin
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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