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    [{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"AbbVie Inc","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Oncology","graph2":"Discovery Platform","graph3":"Xilio Therapeutics","amount2":2.1499999999999999,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","amount2New":2.1499999999999999,"dosageForm":"Undisclosed","sponsorNew":"Xilio Therapeutics \/ AbbVie Inc","highestDevelopmentStatusID":"3","companyTruncated":"Xilio Therapeutics \/ AbbVie Inc"},{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Gilead Sciences","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Other Large Molecule","year":"2024","type":"Licensing Agreement","leadProduct":"XTX301","moa":"IL-12 receptor","graph1":"Oncology","graph2":"Phase I","graph3":"Xilio 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    Find Clinical Drug Pipeline Developments & Deals by Xilio Therapeutics

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    01

    Xilio Therapeutics

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    Lead Product(s) : Undisclosed

    Therapeutic Area : Oncology

    Study Phase : Discovery Platform

    Sponsor : AbbVie Inc

    Deal Size : $2,152.0 million

    Deal Type : Collaboration

    DEALS_DEV arrow-down

    AbbVie, Xilio Partner to Develop Tumor-Activated Immunotherapies

    Details : The collaboration will combine AbbVie's oncology expertise and Xilio's proprietary tumor-activation technology to develop novel immunotherapies, including masked T-cell engagers.

    Product Name : Undisclosed

    Product Type : Antibody

    Upfront Cash : $52.0 million

    February 12, 2025

    Lead Product(s) : Undisclosed

    Therapeutic Area : Oncology

    Highest Development Status : Discovery Platform

    Sponsor : AbbVie Inc

    Deal Size : $2,152.0 million

    Deal Type : Collaboration

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    02

    Xilio Therapeutics

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    Lead Product(s) : Vilastobart,Atezolizumab

    Therapeutic Area : Oncology

    Study Phase : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Xilio Therapeutics Announces Phase 2 Data for Vilastobart in Colorectal Cancer

    Details : XTX101 (vilastobart) is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

    Product Name : XTX101

    Product Type : Antibody

    Upfront Cash : Inapplicable

    January 21, 2025

    Lead Product(s) : Vilastobart,Atezolizumab

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    03

    Xilio Therapeutics

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    Lead Product(s) : XTX301

    Therapeutic Area : Oncology

    Study Phase : Phase I

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Xilio Reports Phase 1 Safety Data for XTX301, Validating Tumor-Activated Therapies

    Details : XTX301 is an investigational tumor-activated IL-12 designed to potently stimulate anti-tumor immunity. It is under phase 1 clinical development for the treatment of advanced solid tumor.

    Product Name : XTX301

    Product Type : Other Large Molecule

    Upfront Cash : Inapplicable

    August 01, 2024

    Lead Product(s) : XTX301

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    04

    Xilio Therapeutics

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    Lead Product(s) : Vilastobart,Atezolizumab

    Therapeutic Area : Oncology

    Study Phase : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Xilio Therapeutics Announces Vilastobart Data in Advanced Solid Tumors

    Details : XTX101 is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

    Product Name : XTX101

    Product Type : Antibody

    Upfront Cash : Inapplicable

    July 11, 2024

    Lead Product(s) : Vilastobart,Atezolizumab

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    05

    Xilio Therapeutics

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    Lead Product(s) : XTX301

    Therapeutic Area : Oncology

    Study Phase : Phase I

    Sponsor : Gilead Sciences

    Deal Size : $647.5 million

    Deal Type : Licensing Agreement

    DEALS_DEV arrow-down

    Gilead and Xilio Announce Exclusive License Agreement for Tumor-Activated IL-12 Program

    Details : Gilead has an exclusive global license to develop and commercialize XTX301, Xilio’s tumor-activated IL-12, currently in Phase I trials for neoplasms treatment.

    Product Name : XTX301

    Product Type : Other Large Molecule

    Upfront Cash : $43.5 million

    March 28, 2024

    Lead Product(s) : XTX301

    Therapeutic Area : Oncology

    Highest Development Status : Phase I

    Sponsor : Gilead Sciences

    Deal Size : $647.5 million

    Deal Type : Licensing Agreement

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    06

    Xilio Therapeutics

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    Lead Product(s) : Vilastobart,Atezolizumab

    Therapeutic Area : Oncology

    Study Phase : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Xilio Therapeutics Announces Initiation of Enrollment for Phase 1 Combination Trial of XTX101, a Tumor-Activat...

    Details : XTX101 is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

    Product Name : XTX101

    Product Type : Antibody

    Upfront Cash : Inapplicable

    July 12, 2023

    Lead Product(s) : Vilastobart,Atezolizumab

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Xilio Therapeutics

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    Lead Product(s) : Vilastobart,Pembrolizumab

    Therapeutic Area : Oncology

    Study Phase : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Xilio Therapeutics Announces Preliminary Clinical Data from Phase 1 Trial of XTX101, a Tumor-Activated, Fc-Enh...

    Details : XTX101 is an investigational tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody designed to deplete regulatory T cells when activated (unmasked) in the tumor microenvironment (TME).

    Product Name : XTX101

    Product Type : Antibody

    Upfront Cash : Inapplicable

    May 25, 2023

    Lead Product(s) : Vilastobart,Pembrolizumab

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Xilio Therapeutics

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    Lead Product(s) : XTX202

    Therapeutic Area : Oncology

    Study Phase : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Xilio Therapeutics Announces Initiation of Patient Dosing in Phase 1/2 Clinical Trial of XTX202 for the Treatm...

    Details : In preclinical studies, XTX202 exhibited tumor-selective biological activity and anti-tumor activity comparable to aldesleukin, a high-dose IL-2 therapy, at its maximum tolerated dose, while minimizing the severe toxicity observed with aldesleukin.

    Product Name : XTX202

    Product Type : Protein

    Upfront Cash : Inapplicable

    January 20, 2022

    Lead Product(s) : XTX202

    Therapeutic Area : Oncology

    Highest Development Status : Phase I/ Phase II

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    09

    Xilio Therapeutics

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    Lead Product(s) : Vilastobart

    Therapeutic Area : Oncology

    Study Phase : Preclinical

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    Xilio Presents Preclinical Tumor-Selective Activity and Tolerability Data for XTX101 at Frontiers in Cancer Im...

    Details : Preclinical studies of XTX101, its tumor-selective anti-CTLA-4 antibody, demonstrating combination potential with anti-PD-1 therapy, as well as enhanced preclinical activity and improved tolerability compared to ipilimumab.

    Product Name : XTX101

    Product Type : Antibody

    Upfront Cash : Inapplicable

    December 05, 2021

    Lead Product(s) : Vilastobart

    Therapeutic Area : Oncology

    Highest Development Status : Preclinical

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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    Xilio Therapeutics

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    Lead Product(s) : XTX202

    Therapeutic Area : Oncology

    Study Phase : IND Enabling

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

    DEALS_DEV arrow-down

    US FDA Clears Xilio Therapeutics’ IND Application for XTX202 to Treat Solid Tumors

    Details : XTX202 is tumor-selective IL-2 product candidate, as a potential treatment for patients with solid tumors. XTX202 is designed to localize activity in the tumor microenvironment (TME).

    Product Name : XTX202

    Product Type : Protein

    Upfront Cash : Inapplicable

    October 18, 2021

    Lead Product(s) : XTX202

    Therapeutic Area : Oncology

    Highest Development Status : IND Enabling

    Sponsor : Inapplicable

    Deal Size : Inapplicable

    Deal Type : Inapplicable

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