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    [{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Takeda Ventures","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Series B Financing","leadProduct":"XTX201","moa":"IL-2","graph1":"Oncology","graph2":"Preclinical","graph3":"Xilio Therapeutics","amount2":0.10000000000000001,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0.10000000000000001,"dosageForm":"","sponsorNew":"Xilio Therapeutics \/ Takeda Ventures","highestDevelopmentStatusID":"4","companyTruncated":"Xilio Therapeutics \/ Takeda Ventures"},{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2020","type":"Not Applicable","leadProduct":"XTX201","moa":"IL-2","graph1":"Oncology","graph2":"Preclinical","graph3":"Xilio 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Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Xilio Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Xilio Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"Atezolizumab","moa":"","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Xilio Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Xilio Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"7","companyTruncated":"Xilio Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Inapplicable","leadProduct":"Atezolizumab","moa":"||CTLA-4","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Xilio Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"","sponsorNew":"Xilio Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"7","companyTruncated":"Xilio Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Xilio Therapeutics","sponsor":"AbbVie Inc","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Collaboration","leadProduct":"Undisclosed","moa":"","graph1":"Oncology","graph2":"Discovery Platform","graph3":"Xilio Therapeutics","amount2":2.1499999999999999,"highestDevelopmentShortName":"Discovery Platform","therapeuticAreaShortName":"Oncology","amount2New":2.1499999999999999,"dosageForm":"","sponsorNew":"Xilio Therapeutics \/ Abbvie Inc","highestDevelopmentStatusID":"3","companyTruncated":"Xilio Therapeutics \/ Abbvie Inc"}]

    Find Clinical Drug Pipeline Developments & Deals by Xilio Therapeutics

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                            01

                            Xilio Therapeutics

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                            Xilio Therapeutics

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Discovery Platform

                            Sponsor : AbbVie Inc

                            Deal Size : $2,152.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            AbbVie, Xilio Partner to Develop Tumor-Activated Immunotherapies

                            Details : The collaboration will combine AbbVie's oncology expertise and Xilio's proprietary tumor-activation technology to develop novel immunotherapies, including masked T-cell engagers.

                            Product Name : Undisclosed

                            Product Type : Antibody

                            Upfront Cash : $52.0 million

                            February 12, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Discovery Platform

                            Sponsor : AbbVie Inc

                            Deal Size : $2,152.0 million

                            Deal Type : Collaboration

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                            02

                            Xilio Therapeutics

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                            Xilio Therapeutics

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                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Phase 2 Data for Vilastobart in Colorectal Cancer

                            Details : XTX101 (vilastobart) is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                            Product Name : XTX101

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            January 21, 2025

                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Xilio Therapeutics

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                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Vilastobart Data in Advanced Solid Tumors

                            Details : XTX101 is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                            Product Name : XTX101

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            November 07, 2024

                            Lead Product(s) : Vilastobart,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            Xilio Therapeutics

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                            Xilio Therapeutics

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                            Lead Product(s) : XTX301

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Gilead Sciences

                            Deal Size : $647.5 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Gilead and Xilio Announce Exclusive License Agreement for Tumor-Activated IL-12 Program

                            Details : Gilead has an exclusive global license to develop and commercialize XTX301, Xilio’s tumor-activated IL-12, currently in Phase I trials for neoplasms treatment.

                            Product Name : XTX301

                            Product Type : Large molecule

                            Upfront Cash : $43.5 million

                            March 28, 2024

                            Lead Product(s) : XTX301

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Gilead Sciences

                            Deal Size : $647.5 million

                            Deal Type : Licensing Agreement

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                            05

                            Xilio Therapeutics

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                            Xilio Therapeutics

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                            Lead Product(s) : XTX301

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Xilio Reports Phase 1 Safety Data for XTX301, Validating Tumor-Activated Therapies

                            Details : XTX301 is an investigational tumor-activated IL-12 designed to potently stimulate anti-tumor immunity. It is under phase 1 clinical development for the treatment of advanced solid tumor.

                            Product Name : XTX301

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 08, 2024

                            Lead Product(s) : XTX301

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            Xilio Therapeutics

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                            Lead Product(s) : XTX101,Atezolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Initiation of Enrollment for Phase 1 Combination Trial of XTX101, a Tumor-Activat...

                            Details : XTX101 is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                            Product Name : XTX101

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 07, 2023

                            Lead Product(s) : XTX101,Atezolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            Xilio Therapeutics

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                            Lead Product(s) : XTX101,Pembrolizumab

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Preliminary Clinical Data from Phase 1 Trial of XTX101, a Tumor-Activated, Fc-Enh...

                            Details : XTX101 is an investigational tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody designed to deplete regulatory T cells when activated (unmasked) in the tumor microenvironment (TME).

                            Product Name : XTX101

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 25, 2023

                            Lead Product(s) : XTX101,Pembrolizumab

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            Xilio Therapeutics

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                            Lead Product(s) : XTX202

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Xilio Therapeutics Announces Initiation of Patient Dosing in Phase 1/2 Clinical Trial of XTX202 for the Treatm...

                            Details : In preclinical studies, XTX202 exhibited tumor-selective biological activity and anti-tumor activity comparable to aldesleukin, a high-dose IL-2 therapy, at its maximum tolerated dose, while minimizing the severe toxicity observed with aldesleukin.

                            Product Name : XTX202

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 20, 2022

                            Lead Product(s) : XTX202

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            Xilio Therapeutics

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                            Lead Product(s) : XTX202

                            Therapeutic Area : Oncology

                            Study Phase : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            US FDA Clears Xilio Therapeutics’ IND Application for XTX202 to Treat Solid Tumors

                            Details : XTX202 is tumor-selective IL-2 product candidate, as a potential treatment for patients with solid tumors. XTX202 is designed to localize activity in the tumor microenvironment (TME).

                            Product Name : XTX202

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            October 18, 2021

                            Lead Product(s) : XTX202

                            Therapeutic Area : Oncology

                            Highest Development Status : IND Enabling

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            10

                            Xilio Therapeutics

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                            Lead Product(s) : XTX101

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Xilio Presents Preclinical Tumor-Selective Activity and Tolerability Data for XTX101 at Frontiers in Cancer Im...

                            Details : Preclinical studies of XTX101, its tumor-selective anti-CTLA-4 antibody, demonstrating combination potential with anti-PD-1 therapy, as well as enhanced preclinical activity and improved tolerability compared to ipilimumab.

                            Product Name : XTX101

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            May 12, 2021

                            Lead Product(s) : XTX101

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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