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Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody","year":"2021","type":"Inapplicable","leadProduct":"Vilastobart","moa":"CTLA-4","graph1":"Oncology","graph2":"Preclinical","graph3":"Xilio Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Xilio Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"Xilio Therapeutics \/ Inapplicable"}]

Find Clinical Drug Pipeline Developments & Deals by Xilio Therapeutics

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                          Top Deals by Deal Size (USD bn)

                          01

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : The collaboration will combine AbbVie's oncology expertise and Xilio's proprietary tumor-activation technology to develop novel immunotherapies, including masked T-cell engagers.

                          Product Name : Undisclosed

                          Product Type : Antibody

                          Upfront Cash : $52.0 million

                          February 12, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Discovery Platform

                          Sponsor : AbbVie Inc

                          Deal Size : $2,152.0 million

                          Deal Type : Collaboration

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                          02

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XTX101 (vilastobart) is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                          Product Name : XTX101

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          January 21, 2025

                          Lead Product(s) : Vilastobart,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XTX301 is an investigational tumor-activated IL-12 designed to potently stimulate anti-tumor immunity. It is under phase 1 clinical development for the treatment of advanced solid tumor.

                          Product Name : XTX301

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          August 01, 2024

                          Lead Product(s) : XTX301

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XTX101 is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                          Product Name : XTX101

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          July 11, 2024

                          Lead Product(s) : Vilastobart,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Gilead has an exclusive global license to develop and commercialize XTX301, Xilio’s tumor-activated IL-12, currently in Phase I trials for neoplasms treatment.

                          Product Name : XTX301

                          Product Type : Other Large Molecule

                          Upfront Cash : $43.5 million

                          March 28, 2024

                          Lead Product(s) : XTX301

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Gilead Sciences

                          Deal Size : $647.5 million

                          Deal Type : Licensing Agreement

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                          06

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XTX101 is an antibody infusion therapy inhibiting CTLA-4, is being investigated for the treatment of microsatellite stable colorectal cancer in combination with Atezolizumab.

                          Product Name : XTX101

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          July 12, 2023

                          Lead Product(s) : Vilastobart,Atezolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XTX101 is an investigational tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody designed to deplete regulatory T cells when activated (unmasked) in the tumor microenvironment (TME).

                          Product Name : XTX101

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          May 25, 2023

                          Lead Product(s) : Vilastobart,Pembrolizumab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : In preclinical studies, XTX202 exhibited tumor-selective biological activity and anti-tumor activity comparable to aldesleukin, a high-dose IL-2 therapy, at its maximum tolerated dose, while minimizing the severe toxicity observed with aldesleukin.

                          Product Name : XTX202

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          January 20, 2022

                          Lead Product(s) : XTX202

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : Preclinical studies of XTX101, its tumor-selective anti-CTLA-4 antibody, demonstrating combination potential with anti-PD-1 therapy, as well as enhanced preclinical activity and improved tolerability compared to ipilimumab.

                          Product Name : XTX101

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          December 05, 2021

                          Lead Product(s) : Vilastobart

                          Therapeutic Area : Oncology

                          Highest Development Status : Preclinical

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          AACR Annual meeting
                          Not Confirmed
                          AACR Annual meeting
                          Not Confirmed

                          Details : XTX202 is tumor-selective IL-2 product candidate, as a potential treatment for patients with solid tumors. XTX202 is designed to localize activity in the tumor microenvironment (TME).

                          Product Name : XTX202

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          October 18, 2021

                          Lead Product(s) : XTX202

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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