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    [{"orgOrder":0,"company":"YolTech Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"CHINA","productType":"Large molecule","year":"2024","type":"Not Applicable","leadProduct":"YOLT-201","moa":"","graph1":"Genetic Disease","graph2":"Phase I","graph3":"YolTech Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Genetic Disease","amount2New":0,"dosageForm":"Infusion","sponsorNew":"YolTech Therapeutics \/ Not Applicable","highestDevelopmentStatusID":"6","companyTruncated":"YolTech Therapeutics \/ Not Applicable"},{"orgOrder":0,"company":"YolTech Therapeutics","sponsor":"Not Applicable","pharmaFlowCategory":"DU","therapeuticArea":"Genetic Disease","country":"CHINA","productType":"Cell and Gene therapy","year":"2024","type":"Not Applicable","leadProduct":"YOLT-101","moa":"","graph1":"Genetic Disease","graph2":"Phase I","graph3":"YolTech 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    Find Clinical Drug Pipeline Developments & Deals by YolTech Therapeutics

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                            01

                            YolTech Therapeutics

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                            Lead Product(s) : YOLT-203

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase I

                            Sponsor : Northwestern University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            YolTech Reports Positive Clinical Data for YOLT-203 Gene Therapy in PH1

                            Details : YOLT-203 is an innovative in vivo gene editing therapy, which is currently being evaluated for the treatment of patients with primary hyperoxaluria type 1 (PH1).

                            Product Name : YOLT-203

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : YOLT-203

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase I

                            Sponsor : Northwestern University

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            YolTech Therapeutics

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                            Lead Product(s) : YOLT-204

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            YolTech Initiates Trial for YOLT-204, Bone Marrow-Targeted Gene Editing for β-Thalassemia

                            Details : YOLT-204 is an off-the-shelf in vivo gene editing therapy developed for TDT, it delivers a gene editor to hematopoietic stem cells which helps to induce expression of fetal hemoglobin.

                            Product Name : YOLT-204

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            January 21, 2025

                            Lead Product(s) : YOLT-204

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            YolTech Therapeutics

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                            Lead Product(s) : YOLT-201

                            Therapeutic Area : Rare Diseases and Disorders

                            Study Phase : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            YolTech Therapeutics Announces Successful Dose Escalation in Phase I Trial Of YOLT-201

                            Details : YOLT-201 Injection is a TTR inhibitor oligonucleotide drug candidate. It is being evaluated for the treatment of Transthyretin Amyloidosis Cardiomyopathy.

                            Product Name : YOLT-201

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            December 21, 2024

                            Lead Product(s) : YOLT-201

                            Therapeutic Area : Rare Diseases and Disorders

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            YolTech Therapeutics

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                            Pittcon 2025
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                            Lead Product(s) : YOLT-101

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : SHENZHEN SALUBRIS PHARMACEUTICALS

                            Deal Size : $145.3 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            YolTech Signs Licensing Deal with Salubris For YOLT-101 in China

                            Details : YolTech will continue to advance the preclinical development of YOLT-101, while Salubris will be responsible for preparing and conducting clinical trials within the licensed territory.

                            Product Name : YOLT-101

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            August 27, 2024

                            Lead Product(s) : YOLT-101

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : SHENZHEN SALUBRIS PHARMACEUTICALS

                            Deal Size : $145.3 million

                            Deal Type : Licensing Agreement

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                            05

                            YolTech Therapeutics

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                            Lead Product(s) : YOLT-203

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            YolTech Administers First Dose of Gene Editing Therapy YOLT-203 for PH1

                            Details : YOLT-203 is an innovative in vivo gene editing therapy, which is currently being evaluated for the treatment of patients with primary hyperoxaluria type 1 (PH1).

                            Product Name : YOLT-203

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            August 22, 2024

                            Lead Product(s) : YOLT-203

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

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                            Lead Product(s) : YOLT-201

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            First Patient Dosed in Phase I Clinical Trial of YOLT-201

                            Details : YOLT-201 Injection is a TTR inhibitor oligonucleotide drug candidate. It is being evaluated for the treatment of Transthyretin Amyloidosis Cardiomyopathy.

                            Product Name : YOLT-201

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            July 11, 2024

                            Lead Product(s) : YOLT-201

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            YolTech Therapeutics

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                            Lead Product(s) : YOLT-101

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            First Patient Dosed in Clinical Trial of YOLT-101 for the Treatment of FH

                            Details : YOLT-101, the company's in vivo genome editing candidate being developed as a single dose, potentially curative therapy for the treatment of high-risk heterozygous familial hypercholesterolemia.

                            Product Name : YOLT-101

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Not Applicable

                            April 02, 2024

                            Lead Product(s) : YOLT-101

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            08

                            YolTech Therapeutics

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                            Lead Product(s) : YOLT-201

                            Therapeutic Area : Genetic Disease

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Landmark Clinical Approval for YOLT-201 Obtained by the NMPA

                            Details : YOLT-201 Injection uses lipid nanoparticles to encapsulate mRNA and sgRNA, forming LNP, and is being evaluated for treating Transthyretin Amyloidosis Cardiomyopathy.

                            Product Name : YOLT-201

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 04, 2024

                            Lead Product(s) : YOLT-201

                            Therapeutic Area : Genetic Disease

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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