Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : ZEN003694,Talazoparib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : National Cancer Institute
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ZEN-3694 (ZEN003694), orally bioavailable small molecule, in initro studies selectively binds to BET proteins with >20 fold selectivity over non-BET bromodomains inhibiting interaction of acetylated histone peptide with IC50 values in low nM range.
Brand Name : ZEN-3694
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 06, 2022
Lead Product(s) : ZEN003694,Talazoparib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : National Cancer Institute
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ZEN-3694,Talazoparib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The combination regimen of ZEN-3694 (ZEN003694) + talazoparib has shown promising clinical activity in a mTNBC patient population with significant unmet need. This combination is active with a manageable safety profile and warrants continued clinical eva...
Brand Name : ZEN003694
Molecule Type : Small molecule
Upfront Cash : Not Applicable
June 21, 2022
Lead Product(s) : ZEN-3694,Talazoparib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ZEN-3694,Talazoparib
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Pfizer Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : The data from the Phase 1b/2 trial has shown that the ZEN003694 (ZEN-3694) plus talazoparib combination regimen induced durable responses in tumors of TNBC patients which do not harbor mutations in BRCA1/2.
Brand Name : ZEN003694
Molecule Type : Small molecule
Upfront Cash : Not Applicable
May 10, 2022
Lead Product(s) : ZEN-3694,Talazoparib
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Pfizer Inc
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : ZEN-3694,Nivolumab,Ipilimumab
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : The Division of Cancer Treatment and Diagnosis
Deal Size : Undisclosed
Deal Type : Agreement
Details : First clinical Study to Combine ZEN-3694 with BMS’s immune checkpoint inhibitors nivolumab and ipilimumab for treatment of ovarian cancer.
Brand Name : ZEN-3694
Molecule Type : Small molecule
Upfront Cash : Undisclosed
October 05, 2020
Lead Product(s) : ZEN-3694,Nivolumab,Ipilimumab
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : The Division of Cancer Treatment and Diagnosis
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : ZEN003694,Enzalutamide,Pembrolizumab
Therapeutic Area : Oncology
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Zenith Epigenetics Advances ZEN-3694 in Multiple Cancer Programs
Details : Merck, Pfizer, UCSF and Newsoara join the list of collaborators involved in Zenith's development of ZEN-3694 in epigenetic combination therapy programs.
Brand Name : ZEN-3694
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 29, 2020
Lead Product(s) : ZEN003694,Enzalutamide,Pembrolizumab
Therapeutic Area : Oncology
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
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