Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
NewAmsterdam Pharma Completes Enrollment in Phase 3 TANDEM Trial for Obicetrapib
Details : TA-8995 (obicetrapib), CETP inhibitor, in combination with Ezetimibe, is being evaluated for the treatment of Heterozygous Familial Hypercholesterolemia, Atherosclerotic Cardiovascular Disease.
Brand Name : TA-8995
Molecule Type : Small molecule
Upfront Cash : Not Applicable
July 08, 2024
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
NewAmsterdam Doses First Patient in Phase 3 TANDEM Trial for Obicetrapib
Details : NewAmsterdam TA-8995 (obicetrapib) is a CETP inhibitor combined with Ezetimibe, under evaluation in Phase III trials for Heterozygous Familial Hypercholesterolemia and cardiovascular disease.
Brand Name : TA-8995
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 12, 2024
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase III
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Rosuvastatin,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Rosuzet is a combination of rosuvastatin is an inhibitor of HMG CoA-reductase, the rate-limiting enzyme that converts the precursor of cholesterol and ezetimibe, a sterol transporter, NPC1L1, which is involved in the intestinal uptake of cholesterol.
Brand Name : Rosuzet
Molecule Type : Small molecule
Upfront Cash : Not Applicable
March 17, 2023
Lead Product(s) : Rosuvastatin,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : TA-8995 (obicetrapib) is a next-generation, non statin, oral once-daily, low-dose CETP inhibitor having the potential for lowering LDL-C, if approved. It is currently being investigated in combination with ezetimibe as an adjunct to high-intensity statin...
Brand Name : TA-8995
Molecule Type : Small molecule
Upfront Cash : Not Applicable
January 17, 2023
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : Obicetrapib (TA-8995) is an oral, low-dose and once-daily CETP inhibitor, initially in development for patients at high risk for cardiovascular disease as an adjunct to maximally tolerated statin therapy, both as a monotherapy and in a fixed-dose combina...
Brand Name : TA-8995
Molecule Type : Small molecule
Upfront Cash : Not Applicable
October 05, 2022
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Details : ROSE2 study evaluates obicetrapib, a novel cholesteryl ester transfer protein (CETP) inhibitor, in combination with ezetimibe, a cholesterol absorption inhibitor, in patients who are currently receiving high-intensity statin therapy.
Brand Name : TA-8995
Molecule Type : Small molecule
Upfront Cash : Not Applicable
April 05, 2022
Lead Product(s) : Obicetrapib,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Phase II
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Inclisiran,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Approved
Sponsor : Alnylam Pharmaceuticals
Deal Size : Not Applicable
Deal Type : Not Applicable
Leqvio®* (Inclisiran) Reduced LDL-C in People who Are Overweight or Obese
Details : Treatment emergent adverse events (TEAEs) at the injection site were more frequent with Leqvio, but all were mild or moderate. The effect of Leqvio on cardiovascular morbidity and mortality has not been determined.
Brand Name : Leqvio
Molecule Type : Large molecule
Upfront Cash : Not Applicable
November 08, 2021
Lead Product(s) : Inclisiran,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Approved
Sponsor : Alnylam Pharmaceuticals
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Bempedoic Acid,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Esperion to Present Key Science at the American Heart Association Scientific Sessions 2021
Details : Bempedoic acid is indicated as an adjunct to diet and maximally tolerated statin therapy for the treatment of adults with heterozygous familial hypercholesterolemia or established atherosclerotic cardiovascular disease who require additional lowering of ...
Brand Name : Nexlizet
Molecule Type : Small molecule
Upfront Cash : Not Applicable
November 01, 2021
Lead Product(s) : Bempedoic Acid,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Approved
Sponsor : Not Applicable
Deal Size : Not Applicable
Deal Type : Not Applicable
Lead Product(s) : Inclisiran,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Approved
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : Undisclosed
Deal Type : Collaboration
Details : Agreement follows positive NICE recommendation and commits to deliver Leqvio® (inclisiran) access via a population health management approach identifying eligible patients across England.
Brand Name : Leqvio
Molecule Type : Large molecule
Upfront Cash : Undisclosed
September 01, 2021
Lead Product(s) : Inclisiran,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Approved
Sponsor : Novartis Pharmaceuticals Corporation
Deal Size : Undisclosed
Deal Type : Collaboration
Lead Product(s) : Bempedoic Acid,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Study Phase : Approved
Sponsor : Daiichi Sankyo
Deal Size : $1,130.0 million
Deal Type : Partnership
Esperion Expands Partnership with Daiichi Sankyo Group to Additional Territories
Details : The agreement combines Esperion Therapeutics’ first-in-class ATP Citrate Lyase (ACL) inhibitor, bempedoic acid, with Daiichi Sankyo’s commercial capabilities, as well as synergies with their existing portfolio of cardiovascular medicines.
Brand Name : Nexlizet
Molecule Type : Small molecule
Upfront Cash : $30.0 million
April 26, 2021
Lead Product(s) : Bempedoic Acid,Ezetimibe
Therapeutic Area : Cardiology/Vascular Diseases
Highest Development Status : Approved
Sponsor : Daiichi Sankyo
Deal Size : $1,130.0 million
Deal Type : Partnership
LOOKING FOR A SUPPLIER?