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Inc","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Neurology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"ZyVersa Therapeutics, Inc \/ Inapplicable","highestDevelopmentStatusID":"4","companyTruncated":"ZyVersa Therapeutics, Inc \/ Inapplicable"}]

    Find Clinical Drug Pipeline Developments & Deals by ZyVersa Therapeutics, Inc

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                            01

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZyVersa Data Shows Inflammasome Inhibition Lowers Neuroinflammation in Alzheimer’s

                            Details : IC 100 is a NLRP3-inflammasome inhibitor, small molecule drug candidate, which is currently being evaluated for the treatment of alzheimer’s disease.

                            Product Name : IC 100

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 12, 2025

                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC 100

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ZyVersa's NLRP3 Inhibitor Shows Heart, Glucose Benefits in Obese Models

                            Details : MCC950 is a NLRP3-inflammasome inhibitor, small molecule drug candidate, which is currently being evaluated for the treatment of heart failure (HFpEF) and type 2 diabetes.

                            Product Name : IC 100

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 05, 2025

                            Lead Product(s) : IC 100

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Preclinical

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ZyVersa Gets IRB Approval for Phase 2a Trial Of VAR 200 in Diabetic Kidney Disease

                            Details : VAR 200 (2-hydroxypropyl-beta-cyclodextrin) is being developed to mediate removal of excess cholesterol that damages the kidneys’ filtration system in patients with Diabetic Kidney Disease.

                            Product Name : VAR 200

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            March 18, 2024

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase I

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            04

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC 100-08

                            Therapeutic Area : Nutrition and Weight Loss

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $2.7 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            ZyVersa Raises $2.7M as Inflammasome Inhibitors Show Promise for Obesity Treatment

                            Details : The net proceeds will be used to focus on the clinical development of IC 100-08, a novel humanized IgG4 monoclonal antibody. Currently, it is being evaluated in the preclinical studies for obesity.

                            Product Name : IC 100-08

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            February 29, 2024

                            Lead Product(s) : IC 100-08

                            Therapeutic Area : Nutrition and Weight Loss

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : $2.7 million

                            Deal Type : Private Placement

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                            05

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase I

                            Sponsor : George Clinical

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ZyVersa Therapeutics Engages CRO, George Clinical, for Phase 2a Clinical Trial for Cholesterol Efflux Mediator...

                            Details : VAR 200 (2-hydroxypropyl-beta-cyclodextrin, 2HPβCD) is a phase 2a-ready drug in development which has potential to treat multiple kidney diseases, including diabetic kidney disease, rare kidney diseases, FSGS (focal segmental glomerulosclerosis) and Alp...

                            Product Name : VAR 200

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            December 14, 2023

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase I

                            Sponsor : George Clinical

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            06

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ZyVersa Therapeutics Adds Two Esteemed Leaders in Nephrology to Its Renal Scientific Advisory Board to Support...

                            Details : VAR 200 (2HPβCD) is a cholesterol efflux mediator in development to ameliorate renal lipid accumulation that damages the kidneys' filtration system. VAR 200 passively and actively removes excess lipids from the kidney and has potential to treat other gl...

                            Product Name : VAR 200

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            January 03, 2023

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Not Applicable

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            07

                            ZyVersa Therapeutics, Inc

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Study Phase : Phase II

                            Sponsor : Larkspur Health Acquisition

                            Deal Size : $10.0 million

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            ZyVersa Therapeutics and Larkspur Health Acquisition Corp. Announce Business Combination, Interim Financing an...

                            Details : The support will enable company to advance clinical evaluation of cholesterol efflux mediator candidate (VAR 200) in patients with orphan renal disease, FSGS, and to progress the inflammasome ASC inhibitor candidate (IC 100) into Phase 1 trials.

                            Product Name : VAR 200

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            September 27, 2022

                            Lead Product(s) : Hydroxypropyl-Beta Cyclodextrin

                            Therapeutic Area : Nephrology

                            Highest Development Status : Phase II

                            Sponsor : Larkspur Health Acquisition

                            Deal Size : $10.0 million

                            Deal Type : Agreement

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                            08

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Larkspur Health Acquisition Corp

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            Data Published in Frontiers in Molecular Neuroscience Demonstrate That ZyVersa's Inflammasome ASC Inhibitor, I...

                            Details : IC 100, a novel monoclonal antibody inflammasome ASC inhibitor, targets multiple types of inflammasomes, including NLRP1, to block initiation and perpetuation of damaging chronic inflammation.

                            Product Name : IC 100

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 22, 2022

                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Larkspur Health Acquisition Corp

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            09

                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : Larkspur Health Acquisition Corp

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

                            DEALS_DEV arrow-down

                            ZyVersa's Proprietary Inflammasome ASC Inhibitor's Differentiated Mechanism of Action Featured in Translationa...

                            Details : IC 100, a novel monoclonal antibody inflammasome ASC inhibitor, targets multiple types of inflammasomes to block initiation and perpetuation of damaging chronic inflammation.

                            Product Name : IC 100

                            Product Type : Large molecule

                            Upfront Cash : Not Applicable

                            August 03, 2022

                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : Larkspur Health Acquisition Corp

                            Deal Size : Not Applicable

                            Deal Type : Not Applicable

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                            ZyVersa Therapeutics, Inc

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                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Study Phase : Preclinical

                            Sponsor : University of Miami

                            Deal Size : Undisclosed

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            ZyVersa Therapeutics and University of Miami Awarded a Grant from The Michael J. Fox Foundation to Determine i...

                            Details : IC 100, a CNS-penetrating monoclonal ASC Inhibitor, targets multiple types of inflammasomes to block initiation and perpetuation of damaging chronic inflammation.

                            Product Name : IC 100

                            Product Type : Large molecule

                            Upfront Cash : Undisclosed

                            July 27, 2022

                            Lead Product(s) : IC 100

                            Therapeutic Area : Neurology

                            Highest Development Status : Preclinical

                            Sponsor : University of Miami

                            Deal Size : Undisclosed

                            Deal Type : Funding

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