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Calsil

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ACTIVE PHARMA INGREDIENTS

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Chemistry

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Also known as: 1344-95-2, Micro-cel, Dicalcium;silicate, Calcium silicate [nf], Calsil, Calcium silicate (nf)

Molecular Formula

Ca₂O₄Si

Molecular Weight

172.24 g/mol

InChI Key

JHLNERQLKQQLRZ-UHFFFAOYSA-N

FDA UNII

9W3UX8K5UQ

1 2D Structure

Calsil

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

dicalcium;silicate

2.1.2 InChI

InChI=1S/2Ca.O4Si/c;;1-5(2,3)4/q2*+2;-4

2.1.3 InChI Key

JHLNERQLKQQLRZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

[O-][Si]([O-])([O-])[O-].[Ca+2].[Ca+2]

2.2 Other Identifiers

2.2.1 UNII

9W3UX8K5UQ

2.3 Synonyms

2.3.1 Depositor-Supplied Synonyms

1. 1344-95-2

2. Micro-cel

3. Dicalcium;silicate

4. Calcium Silicate [nf]

5. Calsil

6. Calcium Silicate (nf)

7. Cs Lafarge

8. Toyofine A

9. Florite R

10. Microcal Et

11. Starlex L

12. Calflo E

13. Silmos T

14. Silene Ef

15. Micro-cel A

16. Micro-cel B

17. Micro-cel C

18. Micro-cel E

19. Micro-cel T

20. Promaxon P60

21. Calcium Monosilicate

22. Calcium Polysilicate

23. Stabinex Nw 7ps

24. Marimet 45

25. Micro-cel T26

26. Micro-cel T38

27. Micro-cel T41

28. Microcal 160

29. Calcium Hydrosilicate

30. Silicic Acid Calcium Salt

31. Hsdb 705

32. Einecs 215-710-8

33. Sw 400

34. Calcium Silicate, Synthetic Nonfibrous

35. Calcium Silicate, Synthetic

36. Unii-s4255p4g5m

37. Dicalcium Orthosilicate

38. Ec 215-710-8

39. Dtxsid5049570

40. Nsc 57629

41. Akos015915657

42. D03309

43. Q416365

44. 39433-03-9

2.4 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	Ca₂O₄Si
Molecular Weight	172.24 g/mol
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	0
Exact Mass	171.8817667 g/mol
Monoisotopic Mass	171.8817667 g/mol
Topological Polar Surface Area	92.2 Å²
Heavy Atom Count	7
Formal Charge	0
Complexity	19.1
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Therapeutic Uses

Calcium Silicate is listed in the OTC Active Ingredient Status Report as an external analgesic and skin protectant.

Elmore AR; Cosmetic Ingredient Review Expert Panel; J Am Coll Toxicol 22 (Suppl. 1): 37-102 (2003)

MEDICATION (VET): ... /IT/ HAS ANTACID & ADSORBENT PROPERTIES SIMILAR TO MAGNESIUM SILICATES.

Rossoff, I.S. Handbook of Veterinary Drugs. New York: Springer Publishing Company, 1974., p. 72

5 Pharmacology and Biochemistry

5.1 Absorption, Distribution and Excretion

The substance can be absorbed into the body by inhalation.

International Program on Chemical Safety/Commission of the European Communities; International Chemical Safety Card on Calcium silicate (May 2001). Available from, as of May 20, 2010: https://www.inchem.org/pages/icsc.html

5.2 Biological Half-Life

The biodurability of various glass fibers, rockwool, and ceramic fibers was examined in rat lungs and compared with natural mineral fibers ... Sized fractions of fibers were instilled intratracheally into Wistar rats ... The half-time of fiber elimination from the lung ranges from about 10 days for wollastonite to more than 300 days for crocidolite. The biodurability of man-made vitreous fibers (MMVF) is between these values and is dependent on the chemical composition of the fibers and the diameter and length distribution ...

PMID:7882923 Full text: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1567280 Muhle H et al; Environ Health Perspect 102 Suppl 5: 163-8 (1994).

5.3 Mechanism of Action

Calcium silicate has been considered as a possible replacement for asbestos due to its heat and fire resistance. The cytotoxic and genotoxic potential of calcium silicate using peripheral human blood lymphocytes is described. Calcium silicates at concn of 10 and 100 ug/ml significantly increased the frequencies of chromosomal aberrations and sister chromatid exchanges. The increases in chromosomal aberrations and sister chromatid exchanges were dose-dependent, though not linearly. A significant decrease in the proliferation rate index was observed with increased dose of calcium silicates. The induction of chromatid type aberrations indicates that the clastogenic activity of calcium silicate is S-phase-dependent.

PMID:7683767 Aslam M, Rahman Q; Mutat Res 300 (1): 45-8 (1993)

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