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Also known as: 5053-06-5, Respiride, 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one, Fenspiride [inn], 8-phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one, Eurespal
Molecular Formula
C15H20N2O2
Molecular Weight
260.33  g/mol
InChI Key
FVNFBBAOMBJTST-UHFFFAOYSA-N
FDA UNII
S983QC7HKM

Fenspiride
Fenspiride is an oxazolidinone spiro compound used as a drug in the treatment of certain respiratory diseases. It is approved for use in Russia for the treatment of acute and chronic inflammatory diseases of ENT organs and the respiratory tract (like rhinopharyngitis, laryngitis, tracheobronchitis, otitis and sinusitis), as well as for maintenance treatment of asthma.
1 2D Structure

Fenspiride

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one
2.1.2 InChI
InChI=1S/C15H20N2O2/c18-14-16-12-15(19-14)7-10-17(11-8-15)9-6-13-4-2-1-3-5-13/h1-5H,6-12H2,(H,16,18)
2.1.3 InChI Key
FVNFBBAOMBJTST-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C1CN(CCC12CNC(=O)O2)CCC3=CC=CC=C3
2.2 Other Identifiers
2.2.1 UNII
S983QC7HKM
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 3612 S

2. 3612-s

3. Decaspiride

4. Espiran

5. Fenspiride Hydrochloride

6. Pneumorel

2.3.2 Depositor-Supplied Synonyms

1. 5053-06-5

2. Respiride

3. 8-(2-phenylethyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one

4. Fenspiride [inn]

5. 8-phenethyl-1-oxa-3,8-diaza-spiro[4.5]decan-2-one

6. Eurespal

7. 8-phenethyl-1-oxa-3,8-diazaspiro[4.5]decan-2-one

8. S983qc7hkm

9. Fenspiride (inn)

10. 1-oxa-3,8-diazaspiro(4,5)decan-2-one, 8-(2-phenylethyl)-

11. Viarespan

12. Fenspiridum [inn-latin]

13. Fenspirida [inn-spanish]

14. Fenspirida

15. Fenspiridum

16. 8-phenethyl-1-oxa-3,8-diazaspiro(4.5)decan-2-one

17. Eurespal (tn)

18. Einecs 225-751-3

19. Brn 0533332

20. Spectrum_001260

21. Fenspiride [mi]

22. Prestwick0_000213

23. Prestwick1_000213

24. Prestwick2_000213

25. Prestwick3_000213

26. Spectrum2_001396

27. Spectrum3_001435

28. Spectrum4_000415

29. Spectrum5_001345

30. Lopac-f-6145

31. Unii-s983qc7hkm

32. Fenspiride [who-dd]

33. Lopac0_000496

34. Schembl21016

35. Bspbio_000225

36. Bspbio_003170

37. Kbiogr_000710

38. Kbioss_001740

39. Divk1c_000526

40. Spbio_001412

41. Spbio_002146

42. Bpbio1_000249

43. Chembl576127

44. Zinc1441

45. Dtxsid4023048

46. Chebi:94558

47. Hy-a0027a

48. Kbio1_000526

49. Kbio2_001740

50. Kbio2_004308

51. Kbio2_006876

52. Kbio3_002390

53. Ninds_000526

54. Bcp07882

55. Mfcd00867054

56. Akos013605285

57. Ccg-204587

58. Db08979

59. Sb37403

60. Sdccgsbi-0050480.p004

61. Cas-1151830

62. Idi1_000526

63. Ncgc00015438-01

64. Ncgc00015438-02

65. Ncgc00015438-03

66. Ncgc00015438-04

67. Ncgc00015438-13

68. Ncgc00016988-01

69. Ncgc00162172-01

70. Ac-25697

71. Sbi-0050480.p003

72. Ab00053591

73. Cs-0013596

74. Ft-0650682

75. D07949

76. Ab00053591_10

77. Ab00053591_11

78. 053f065

79. A913266

80. Q518027

81. 8-phenethyl-1-oxa-3,8-diaza-spiro4.5decan-2-one

82. Brd-k26739552-003-05-5

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 260.33 g/mol
Molecular Formula C15H20N2O2
XLogP32.1
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count3
Rotatable Bond Count3
Exact Mass260.152477885 g/mol
Monoisotopic Mass260.152477885 g/mol
Topological Polar Surface Area41.6 Ų
Heavy Atom Count19
Formal Charge0
Complexity318
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Bronchodilator Agents

Agents that cause an increase in the expansion of a bronchus or bronchial tubes. (See all compounds classified as Bronchodilator Agents.)


4.2 ATC Code

R - Respiratory system

R03 - Drugs for obstructive airway diseases

R03B - Other drugs for obstructive airway diseases, inhalants

R03BX - Other drugs for obstructive airway diseases, inhalants

R03BX01 - Fenspiride


R - Respiratory system

R03 - Drugs for obstructive airway diseases

R03D - Other systemic drugs for obstructive airway diseases

R03DX - Other systemic drugs for obstructive airway diseases

R03DX03 - Fenspiride


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