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Chemistry

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Also known as: Uzsi 9, Zs-9 compound, Uzsi-9, Unii-d652zwf066, Zs 9
Molecular Formula
H6Na2O9Si3Zr+2
Molecular Weight
371.50  g/mol
InChI Key
CBTCHTJSGLCFMY-UHFFFAOYSA-N

Sodium Zirconium Cyclosilicate
1 2D Structure

Sodium Zirconium Cyclosilicate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
disodium;2,2,4,4,6,6-hexahydroxy-1,3,5,2,4,6-trioxatrisilinane;zirconium
2.1.2 InChI
InChI=1S/2Na.H6O9Si3.Zr/c;;1-10(2)7-11(3,4)9-12(5,6)8-10;/h;;1-6H;/q2*+1;;
2.1.3 InChI Key
CBTCHTJSGLCFMY-UHFFFAOYSA-N
2.1.4 Canonical SMILES
O[Si]1(O[Si](O[Si](O1)(O)O)(O)O)O.[Na+].[Na+].[Zr]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Lokelma

2. Sodium Zirconium Cyclosilicate

3. Zs-9 Compound

2.2.2 Depositor-Supplied Synonyms

1. Uzsi 9

2. Zs-9 Compound

3. Uzsi-9

4. Unii-d652zwf066

5. Zs 9

2.3 Create Date
2015-06-06
3 Chemical and Physical Properties
Molecular Weight 371.50 g/mol
Molecular Formula H6Na2O9Si3Zr+2
Hydrogen Bond Donor Count6
Hydrogen Bond Acceptor Count9
Rotatable Bond Count0
Exact Mass369.816199 g/mol
Monoisotopic Mass369.816199 g/mol
Topological Polar Surface Area149 Ų
Heavy Atom Count15
Formal Charge2
Complexity131
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count4
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Ion Exchange Resins

High molecular weight, insoluble polymers which contain functional groups that are capable of undergoing exchange reactions (ION EXCHANGE) with either cations or anions. (See all compounds classified as Ion Exchange Resins.)


API SUPPLIERS

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Metrochem API Private Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
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  • fda
  • EDQM
  • WHO-GMP

Virtual BoothMetrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

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Metrochem

02

Macleods Pharmaceuticals Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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Macleods Pharmaceuticals Limited

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
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USDMF arrow-down CEP/COS JDMF EU-WC NDC KDMF VMF Others AUDIT
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03

Lupin Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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Lupin Ltd

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
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04

Laurus Labs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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Laurus Labs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
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05

Hetero Drugs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
Not Confirmed
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Hetero Drugs

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
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Solara Active Pharma Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

Medlab Asia & Asia Health
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Solara Active Pharma Sciences

India

USDMF, CEP/COS, JDMF, EU-WC, NDC, KDMF, VMF, Others

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Medlab Asia & Asia Health
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USDMF

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Hetero Drugs Ltd

India

USDMF

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Medlab Asia & Asia Health
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01

Medlab Asia & Asia Health
Not Confirmed

GDUFA

DMF Review : Complete

Rev. Date : 2022-04-19

Pay. Date : 2022-03-17

DMF Number : 36915

Submission : 2022-03-17

Status : Active

Type : II

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02

Laurus Labs Ltd

India

USDMF

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Medlab Asia & Asia Health
Not Confirmed

02

Medlab Asia & Asia Health
Not Confirmed

GDUFA

DMF Review : Complete

Rev. Date : 2022-01-28

Pay. Date : 2021-11-18

DMF Number : 36438

Submission : 2021-12-10

Status : Active

Type : II

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03

Medlab Asia & Asia Health
Not Confirmed

03

Medlab Asia & Asia Health
Not Confirmed

GDUFA

DMF Review : Complete

Rev. Date : 2022-04-18

Pay. Date : 2022-03-23

DMF Number : 36413

Submission : 2022-03-16

Status : Active

Type : II

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04

Medlab Asia & Asia Health
Not Confirmed

04

Medlab Asia & Asia Health
Not Confirmed

GDUFA

DMF Review : Complete

Rev. Date : 2022-02-16

Pay. Date : 2022-01-13

DMF Number : 36363

Submission : 2021-12-07

Status : Active

Type : II

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Medlab Asia & Asia Health
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NDC API

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SODIUM ZIRCONIUM CYCLOSILICATE

NDC Package Code : 0310-2111

Start Marketing Date : 2021-12-01

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER, FOR SUSPENSION (243kg/243kg)

Marketing Category : BULK INGREDIENT

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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

NDC Package Code : 65977-0132

Start Marketing Date : 2018-05-18

End Marketing Date : 2024-12-31

Dosage Form (Strength) : POWDER (1kg/kg)

Marketing Category : BULK INGREDIENT

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Listed Suppliers

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arrow
Medlab Asia & Asia Health
Not Confirmed
  • fda
  • EDQM
  • WHO-GMP

Virtual BoothMetrochem has been delivering customized volume & quality products to customers across the world, taking utmost care of their needs.

Flag India
Digital Content Digital Content

Sodium Zirconium Cyclosilicate

About the Company :

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product ...

Established in 2004, Metrochem API is one of the fastest-growing APIs, pellets & intermediates manufacturers. It has 6 dedicated manufacturing facilities for its 3 core product groups and has been approved by ISO 9001-2015, USFDA, WHO GMP, Cofepris & Japanese authorities. Metrochem’s in-depth industry knowledge, & hi-tech & advanced infrastructure, helps it provide quality products to its customers. Note: None of the products will be supplied to the countries where this could conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer
Metrochem
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FDF Dossiers

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AstraZeneca

United Kingdom
Medlab Asia & Asia Health
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AstraZeneca

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

Brand Name : LOKELMA

Dosage Form : FOR SUSPENSION;ORAL

Dosage Strength : 5GM/PACKET

Packaging :

Approval Date : 2018-05-18

Application Number : 207078

Regulatory Info : RX

Registration Country : USA

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AstraZeneca

United Kingdom
Medlab Asia & Asia Health
Not Confirmed
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AstraZeneca

United Kingdom
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Medlab Asia & Asia Health
Not Confirmed

SODIUM ZIRCONIUM CYCLOSILICATE

Brand Name : LOKELMA

Dosage Form : FOR SUSPENSION;ORAL

Dosage Strength : 10GM/PACKET

Packaging :

Approval Date : 2018-05-18

Application Number : 207078

Regulatory Info : RX

Registration Country : USA

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AstraZeneca

United Kingdom
Medlab Asia & Asia Health
Not Confirmed
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AstraZeneca

United Kingdom
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Medlab Asia & Asia Health
Not Confirmed

SODIUM ZIRCONIUM CYCLOSILICATE

Brand Name : LOKELMA

Dosage Form : POWDER FOR SUSPENSION

Dosage Strength : 5G/SACHET

Packaging :

Approval Date :

Application Number : 2490714

Regulatory Info : Prescription

Registration Country : Canada

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AstraZeneca

United Kingdom
Medlab Asia & Asia Health
Not Confirmed
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AstraZeneca

United Kingdom
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Medlab Asia & Asia Health
Not Confirmed

SODIUM ZIRCONIUM CYCLOSILICATE

Brand Name : LOKELMA

Dosage Form : POWDER FOR SUSPENSION

Dosage Strength : 10G/SACHET

Packaging :

Approval Date :

Application Number : 2490722

Regulatory Info : Prescription

Registration Country : Canada

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FDA Orange Book

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ASTRAZENECA

United Kingdom
Medlab Asia & Asia Health
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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

Brand Name : LOKELMA

Dosage Form : FOR SUSPENSION;ORAL

Dosage Strength : 5GM/PACKET

Approval Date : 2018-05-18

Application Number : 207078

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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ASTRAZENECA

United Kingdom
Medlab Asia & Asia Health
Not Confirmed
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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

Brand Name : LOKELMA

Dosage Form : FOR SUSPENSION;ORAL

Dosage Strength : 10GM/PACKET

Approval Date : 2018-05-18

Application Number : 207078

RX/OTC/DISCN : RX

RLD : Yes

TE Code :

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Canada

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ASTRAZENECA CANADA INC

United Kingdom
Medlab Asia & Asia Health
Not Confirmed
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ASTRAZENECA CANADA INC

United Kingdom
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Medlab Asia & Asia Health
Not Confirmed

SODIUM ZIRCONIUM CYCLOSILICATE

Brand Name : LOKELMA

Dosage Form : POWDER FOR SUSPENSION

Dosage Strength : 5G/SACHET

Packaging :

Approval Date :

Application Number : 2490714

Regulatory Info : Prescription

Registration Country : Canada

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02

ASTRAZENECA CANADA INC

United Kingdom
Medlab Asia & Asia Health
Not Confirmed
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ASTRAZENECA CANADA INC

United Kingdom
arrow
Medlab Asia & Asia Health
Not Confirmed

SODIUM ZIRCONIUM CYCLOSILICATE

Brand Name : LOKELMA

Dosage Form : POWDER FOR SUSPENSION

Dosage Strength : 10G/SACHET

Packaging :

Approval Date :

Application Number : 2490722

Regulatory Info : Prescription

Registration Country : Canada

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Patents & EXCLUSIVITIES

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US Patents

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ASTRAZENECA

United Kingdom
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 11738044

Drug Substance Claim :

Drug Product Claim :

Application Number : 207078

Patent Use Code : U-2312

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2035-10-14

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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 9592253

Drug Substance Claim : Y

Drug Product Claim :

Application Number : 207078

Patent Use Code : U-2312

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2035-10-14

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Medlab Asia & Asia Health
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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 8877255

Drug Substance Claim : Y

Drug Product Claim :

Application Number : 207078

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2033-10-22

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Medlab Asia & Asia Health
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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
Not Confirmed

SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 11738044

Drug Substance Claim :

Drug Product Claim :

Application Number : 207078

Patent Use Code : U-2312

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2035-10-14

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05

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Medlab Asia & Asia Health
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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 9913860

Drug Substance Claim : Y

Drug Product Claim :

Application Number : 207078

Patent Use Code : U-2312

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2033-10-22

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06

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ASTRAZENECA

United Kingdom
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 11406662

Drug Substance Claim : Y

Drug Product Claim :

Application Number : 207078

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2032-02-10

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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 9861658

Drug Substance Claim :

Drug Product Claim :

Application Number : 207078

Patent Use Code : U-2312

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2032-02-10

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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 10300087

Drug Substance Claim : Y

Drug Product Claim :

Application Number : 207078

Patent Use Code : U-2312

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2035-10-14

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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 8802152

Drug Substance Claim : Y

Drug Product Claim :

Application Number : 207078

Patent Use Code :

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2032-04-19

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ASTRAZENECA

United Kingdom
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Medlab Asia & Asia Health
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SODIUM ZIRCONIUM CYCLOSILICATE

US Patent Number : 9913860

Drug Substance Claim : Y

Drug Product Claim :

Application Number : 207078

Patent Use Code : U-2312

Delist Requested :

Patent Use Description :

Patent Expiration Date : 2033-10-22

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