Find Talabostat Mesylate manufacturers, exporters & distributors on PharmaCompass

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Chemistry

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Also known as: 150080-09-4, Val-boropro, Talabostat (mesylate), Talabostat mesilate, Talabostat mesylate [usan], Methanesulfonic acid ((r)-1-((s)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid (1:1)
Molecular Formula
C10H23BN2O6S
Molecular Weight
310.18  g/mol
InChI Key
OXYYOEIGQRXGPI-WSZWBAFRSA-N
FDA UNII
V8ZG4Y1B51

Talabostat Mesylate
Talabostat Mesylate is the mesylate salt of an orally active small molecule with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines.
1 2D Structure

Talabostat Mesylate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
[(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid;methanesulfonic acid
2.1.2 InChI
InChI=1S/C9H19BN2O3.CH4O3S/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15;1-5(2,3)4/h6-8,14-15H,3-5,11H2,1-2H3;1H3,(H,2,3,4)/t7-,8-;/m0./s1
2.1.3 InChI Key
OXYYOEIGQRXGPI-WSZWBAFRSA-N
2.1.4 Canonical SMILES
B(C1CCCN1C(=O)C(C(C)C)N)(O)O.CS(=O)(=O)O
2.1.5 Isomeric SMILES
B([C@@H]1CCCN1C(=O)[C@H](C(C)C)N)(O)O.CS(=O)(=O)O
2.2 Other Identifiers
2.2.1 UNII
V8ZG4Y1B51
2.3 Synonyms
2.3.1 MeSH Synonyms

1. L-valinyl-l-boroproline

2. Pt 100

3. Pt-100

4. Pt100 Cpd

5. Talabostat

6. Valinyl-boroproline

2.3.2 Depositor-Supplied Synonyms

1. 150080-09-4

2. Val-boropro

3. Talabostat (mesylate)

4. Talabostat Mesilate

5. Talabostat Mesylate [usan]

6. Methanesulfonic Acid ((r)-1-((s)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic Acid (1:1)

7. Pt-100

8. Talabostat Mesylate (usan)

9. V8zg4y1b51

10. Pt100

11. 150080-09-4 (mesylate)

12. [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic Acid Mesylate

13. ((2r)-1-((2s)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic Acid Methanesulfonate

14. (r)-1-((s)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic Acid Methanesulfonic Acid (1:1)

15. Methanesulfonic Acid ((r)-1-((s)-2-amino-3-methyl-butanoyl)pyrrolidin-2-yl)boronic Acid (1:1)

16. Unii-v8zg4y1b51

17. Talabostatmesylate

18. Methanesulfonic Acid Compound With ((r)-1-((s)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic Acid (1:1)

19. Talabostat Methanesulfonic Acid

20. Bxcl 701

21. Schembl4782073

22. Chembl3545064

23. Dtxsid70164466

24. [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic Acid;methanesulfonic Acid

25. Amy14815

26. Bcp04652

27. Ex-a2166

28. Hy-13233a

29. Mfcd13194906

30. S8455

31. Talabostat (val-boropro, Pt-100)

32. Akos016000622

33. Bcp9000205

34. Cs-3187

35. Ac-35958

36. As-73355

37. Talabostat Mesylate; Val-boropro; Pt100

38. Bcp0726000045

39. B3941

40. A14080

41. D05990

42. H11715

43. Val-boropro; Pt100; Pt 100; Pt-100

44. 080t094

45. A903812

46. Q27291679

47. [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic Acid; Methanesulfonic Acid

48. [(2r)-1-[(2s)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic Acidmesylate

49. B-[(2r)-1-[(2s)-2-amino-3-methyl-1-oxobutyl]-2-pyrrolidinyl]boronic Acid Methanesulfonate

50. ((2r)-1-((2s)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic Acid Methanesulphonate

51. Boronic Acid, ((2r)-1-((2s)-2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl) Monomethanesulfonate

52. Boronic Acid, ((2r)-1-((2s)-2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl) Monomethanesulphonate

53. Boronic Acid, ((2r)-1-((2s)-2-amino-3-methyl-1-oxobutyl)-2-pyrrolidinyl)-, Monomethanesulfonate

2.4 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 310.18 g/mol
Molecular Formula C10H23BN2O6S
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count7
Rotatable Bond Count3
Exact Mass310.1369878 g/mol
Monoisotopic Mass310.1369878 g/mol
Topological Polar Surface Area150 Ų
Heavy Atom Count20
Formal Charge0
Complexity328
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2

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ABOUT THIS PAGE

Looking for 150080-09-4 / Talabostat Mesylate API manufacturers, exporters & distributors?

Talabostat Mesylate manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Talabostat Mesylate API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Talabostat Mesylate manufacturer or Talabostat Mesylate supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Talabostat Mesylate manufacturer or Talabostat Mesylate supplier.

PharmaCompass also assists you with knowing the Talabostat Mesylate API Price utilized in the formulation of products. Talabostat Mesylate API Price is not always fixed or binding as the Talabostat Mesylate Price is obtained through a variety of data sources. The Talabostat Mesylate Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Talabostat Mesylate

Synonyms

150080-09-4, Val-boropro, Talabostat (mesylate), Talabostat mesilate, Talabostat mesylate [usan], Methanesulfonic acid ((r)-1-((s)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)boronic acid (1:1)

Cas Number

150080-09-4

Unique Ingredient Identifier (UNII)

V8ZG4Y1B51

About Talabostat Mesylate

Talabostat Mesylate is the mesylate salt of an orally active small molecule with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines.

Talabostat Mesylate Manufacturers

A Talabostat Mesylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Talabostat Mesylate, including repackagers and relabelers. The FDA regulates Talabostat Mesylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Talabostat Mesylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

Talabostat Mesylate Suppliers

A Talabostat Mesylate supplier is an individual or a company that provides Talabostat Mesylate active pharmaceutical ingredient (API) or Talabostat Mesylate finished formulations upon request. The Talabostat Mesylate suppliers may include Talabostat Mesylate API manufacturers, exporters, distributors and traders.

Talabostat Mesylate GMP

Talabostat Mesylate Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Talabostat Mesylate GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Talabostat Mesylate GMP manufacturer or Talabostat Mesylate GMP API supplier for your needs.

Talabostat Mesylate CoA

A Talabostat Mesylate CoA (Certificate of Analysis) is a formal document that attests to Talabostat Mesylate's compliance with Talabostat Mesylate specifications and serves as a tool for batch-level quality control.

Talabostat Mesylate CoA mostly includes findings from lab analyses of a specific batch. For each Talabostat Mesylate CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Talabostat Mesylate may be tested according to a variety of international standards, such as European Pharmacopoeia (Talabostat Mesylate EP), Talabostat Mesylate JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Talabostat Mesylate USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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