Alligator Bioscience released positive data from its Phase Ib/II OPTIMIZE-1 study (NCT04888312) investigating its pancreatic cancer monoclonal antibody therapy, mitazalimab.
Alligator and Aptevo Announce Positive Data of Dose Escalation Ph of ALG.APV-527
Frontline treatment with the combination of the CD40-directed monoclonal antibody agonist mitazalimab and modified FOLFIRINOX (mFOLFIRINOX) continued to produce responses in patients with metastatic pancreatic ductal adenocarcinoma (PDAC), according to updated data from the phase 2 OPTIMIZE-1 trial (NCT04888312).1
Alligator Bioscience (Alligator) has announced an expansion to its licence agreement and research collaboration with Orion Corporation (Orion). The link-up is focused on the discovery and development of new bispecific antibody cancer therapeutics.
LUND, Sweden I January 2, 2023 I Alligator Bioscience (Nasdaq Stockholm: ATORX) today announces strong interim results from the ongoing OPTIMIZE-1 Phase 2 trial of the company’s lead asset mitazalimab in 1st line metastatic pancreatic cancer.
Lund, Sweden, November 8, 2022 – Alligator Bioscience (Nasdaq Stockholm: ATORX) today announces that Shanghai Henlius Biotech, Inc. has received investigational new drug (IND) approval from China's National Medical Products Administration (NMPA) for a Phase 2 clinical trial of AC101 (HLX22), a monoclonal HER2 antibody, in combination with anti-PD-1 monoclonal antibody HANSIZHUANG (serplulimab), HANQUYOU (trastuzumab) and chemotherapy as a 1st line treatment for HER2-positive locally advanced/metastatic gastric cancer patients.
The research involves patients with advanced solid malignancies on tumour-directed therapy. Alligator Bioscience has announced positive safety data from the 900mg dose cohort in its phase 1, first-in-human clinical trial with its drug candidate, ATOR-1017. The treatment is being developed as a tumour-directed therapy for advanced and metastatic cancer.