Memorial Sloan Kettering Cancer Center (MSK) announced today that the U.S. Food and Drug Administration (FDA) has approved the oral MEK inhibitor drug cobimetinib (Cotellic®) for the treatment of adult patients with the family of blood diseases known as histiocytic neoplasms (HN). These diseases include Erdheim-Chester disease, Rosai-Dorfman disease, and Langerhans cell histiocytosis. Cobimetinib is an oral inhibitor of MEK1 and MEK2, currently approved to treat melanoma.
REDWOOD CITY, Calif., Oct. 12, 2020 (GLOBE NEWSWIRE) -- Revolution Medicines, Inc. (Nasdaq: RVMD), a clinical-stage precision oncology company developing targeted therapies to inhibit frontier targets in RAS-addicted cancers, today announced that interim data from the company’s ongoing Phase 1b/2 clinical trial (RMC-4630-02) evaluating the combination of RMC-4630 and cobimetinib (Cotellic®) will be reported in an oral presentation in a plenary session at the upcoming EORTC-NCI-AACR 32nd Symposium on Molecular Targets and Cancer Therapeutics (ENA 2020) being held virtually October 24-25, 2020.
Roche's phase III IMspire150 study of Tecentriq plus Cotellic & Zelboraf for previously untreated BRAF V600 mutation-positive advanced melanoma meets primary endpoint
REVOLUTION Medicines, Inc., a clinical-stage oncology company focused on developing novel targeted therapies to inhibit elusive frontier targets within notorious cancer pathways, today announced dosing of the first patient in an open-label, Phase 1b/2 dose-escalation and dose-expansion study of RMC-4630 in combination with cobimetinib (Cotellic®) in patients with relapsed/refractory solid tumors harboring specific genomic mutations. RMC-4630, a SHP2 inhibitor, and Cotellic®, a MEK inhibitor, are selective inhibitors of oncogenic targets at distinct positions within the RAS signaling cascade that is frequently exploited by human cancers and may develop adaptive resistance to single agent treatment. A combination of these complementary mechanisms of action demonstrated synergistic anti-tumor effects in preclinical cancer models carrying select oncogenic mutations of RAS or associated proteins. These findings provide a compelling scientific rationale to explore the potential of this combination regimen in patients with tumors driven by such mutations.
To little surprise, Exelixis’ Cotellic — known chemically as cobimetinib — in combination with Roche’s Tecentriq, has failed a late-stage study as a frontline treatment for patients with a form of advanced melanoma.
Novartis’ cancer combination Tafinlar and Mekinist has been approved by the EMA for adjuvant treatment of advanced melanoma in order to prevent disease recurrence.
TESARO, Inc. (NASDAQ:TSRO), an oncology-focused biopharmaceutical company, today announced that it has entered into a clinical collaboration with Genentech, a member of the Roche Group, to evaluate the combination of the PD-L1 antibody atezolizumab (TECENTRIQ®), the MEK inhibitor cobimetinib (COTELLIC®) and TESARO’s PARP inhibitor ZEJULA® (niraparib) in patients with platinum-sensitive ovarian cancer.
Drug prices are not just a US problem. Greece's minister of health on Tuesday expressed dismay over Roche's decision to withdraw a cancer medicine because of a new mandatory discount imposed by the country.
Anvisa Suspends Roche`s Trade in lot B1009M8 of The Medicinal Product Cotellic (hemifumarate of cobimetinib)
Enforcement Report - Week of April 12, 2017