Novartis' Generic Tafinlar (Dabrafenib) Receives Approval in the U.S.
CHICAGO & SHANGHAI--(BUSINESS WIRE)--JS InnoPharm Ltd initiated the JSI-1187 plus dabrafenib combination dose-escalation phase of the Phase 1 study for patients with locally advanced or metastatic solid tumors with confirmed BRAF V600E/K mutations (NCT04418167). The clinical study is being conducted at 8 NCI-designated Comprehensive Cancer Centers in the U.S.
Spirita Oncology, LLC Initiates a Phase 1 Clinical Trial of the Anti-Cancer Agent E6201 in Combination with Dabrafenib in Patients with Central Nervous System Metastases from BRAF V600 Mutated Metastatic Melanoma
In the mid-stage trial, 47% of the patients that were given the two drugs Tafinlar and Mekinist saw their tumours shrink, far above a rate of 11% in a comparative group of participants on standard chemotherapy, the drugmaker said on Monday.
Based on unprecedented progression-free survival results, Tafinlar (dabrafenib) + Mekinist (trametinib) confirmed as standard-of-care, targeted therapy for advanced BRAF-mutated melanoma1-4
NICE has announced its recommendation of Bristol-Myers Squibb’s blockbuster immunotherapy drug Opdivo (nivolumab) for the treatment of two non-small cell lung cancer (NSCLC) indications in the second-line, it has emerged.
Basel, September 16, 2020 — Novartis announced previously reported data from the Phase III COMBI-AD study were published today in The New England Journal of Medicine. The study shows more than half of high-risk patients with resected, stage III BRAF V600-mutated melanoma treated with Tafinlar® (dabrafenib) + Mekinist® (trametinib) were alive and relapse-free at 5 years1. Research suggests the majority of relapses in high-risk stage III melanoma generally occur within 5 years1,2.
Novartis has reported data from the Phase III COMBI-i clinical trial of spartalizumab (PDR001) in combination with Tafinlar (dabrafenib) and Mekinist (trametinib) to treat cutaneous melanoma.
Novartis has announced that its investigational immunotherapy spartalizumab in combination with Tafinlar (dabrafenib) and Mekinist (trametinib) failed to improve progression-free survival in patients with advanced melanoma.
HOUSTON -- In a Phase II trial led by researchers at The University of Texas MD Anderson Cancer Center, the combination of dabrafenib, a BRAF inhibitor, and trametinib, a MEK inhibitor, achieved a 51% overall response rate (ORR) in patients with cholangiocarcinoma marked by the BRAF V600E mutation. This trial...