Amphista – a company involved in the development of next generation targeted protein degradation (TPD) therapeutics – has linked up with Domainex in an integrated drug discovery partnership.
Cambridge, UK, 14th September 2022 / Sciad Newswire / Domainex Ltd., based in Cambridge UK, is a leading provider of integrated drug discovery services. As a result of the work carried out by Domainex during an in-house research programme to identify inhibitors of protein kinases TBK1 and IKK-epsilon, DMXD-011 has been nominated as a preclinical drug candidate. The molecule is orally-bioavailable and highly selective. The recent human ex-vivo data outlined below indicates this drug should be effective in the treatment of interferonopathies such as lupus, Sjögren’s syndrome, and scleroderma.
Parkinson’s UK and Domainex have announced a collaboration focused on developing small molecule therapies targeting neuroinflammation, which could slow the progression of Parkinson’s disease.
In selecting Domainex, a UK-based biotechnology company specializing in integrated medicines research, to provide integrated lead optimization services, APEIRON Biologics, a privately held Austrian biotech company focused on cancer and respiratory therapies, will be able to advance the development of inhibitors for the E3 ubiquitin ligase Cbl-b using small-molecule drug discovery.