Pfizer and AstraZeneca have retained their crowns as the most transformative companies in the industry, according (PDF) to IDEA Pharma.
The annual Pharmaceutical Innovation Index measures pretty much the only thing that matters in pharma: did you take assets to market (and to patients) in the past 5 years, and did you do so successfully? Any measures of productivity that miss those two parameters are surrogates, and incredibly misleading.