Following a record 100th year in business, Pfanstiehl has launched high purity, low endotoxin, low metal L-Histidine and L-Histidine Hydrochloride Monohydrate and established a new quality standard for amino acids. Amino acids are critical components utilized in bioprocessing for both upstream and downstream applications. With the ever-increasing regulatory requirements placed on bioprocessing components, there is…
Co-amorphization has recently been shown to be a promising approach for stabilizing amorphous drugs and improving the dissolution rate of poorly water-soluble drugs. In this study, three basic amino acids were chosen as small molecular weight excipients to interact with the drug to form co-amorphous combinations. The co-amorphous combinations of valsartan (VAL) with l-histidine, l-arginine, and l-lysine were prepared by vibrational ball milling. Solid-state characterization with X-ray powder diffraction and differential scanning calorimetry (DSC) revealed that all of the co-amorphous mixtures were homogeneous. The molecular interactions of the co-amorphous mixtures were investigated through the glass transition temperature (Tg) in the DSC measurements and Fourier transform infrared spectroscopy.
Recall: Baxter`s Clinimix (2015-06-19)