A readout from a phase 1b/2a study in humans with obesity has again demonstrated the drug’s anti-inflammatory potential.
NodThera is moving its NLRP3 inhibitors into the clinic after preclinical data showed it reversed obesity and inflammation in mice in a study that compared it against Novo Nordisk’s Wegovy.
LEXINGTON, Mass., Sept. 21, 2022 /PRNewswire/ -- NodThera, a clinical-stage biotechnology company developing a new class of potent and selective oral, small molecule NLRP3 inflammasome inhibitors to treat diseases driven by chronic inflammation, today announced positive Phase 1 clinical readouts for its first and second clinical candidates, NT-0796 and NT-0249. NT-0796 has completed its Phase 1 study confirming brain penetration with excellent pharmacokinetic (PK) & pharmacodynamic (PD) profiles and NT-0249 has completed dosing of the Phase 1 single ascending dose cohorts confirming a potentially best-in-class PK/PD profile and the potential for once-a-day dosing. The results collectively support further development and clinical evaluation in a range of CNS and peripheral inflammatory diseases.
BOSTON and SEATTLE and CAMBRIDGE, England, Nov. 4, 2021 /PRNewswire/ -- NodThera, a clinical-stage biotechnology company developing a new class of medicines that inhibit the NLRP3 inflammasome to treat chronic inflammation, today announced that the first healthy volunteers have been dosed in a Phase 1 clinical trial of its lead investigational candidate, NT-0796.
Earlier this week, Dublin, Ireland-based Inflazome announced that Roche (OTCQX:RHHBY) agreed to acquire it for €380M upfront plus milestones, signaling the biopharma giant's bullishness on an area generating substantial buzz called inflammasomes, innate immune system receptors and sensors that play key roles in a range of inflammatory disorders as well as metabolic and neurodegenerative diseases, including asthma, Parkinson's disease (PD), Alzheimer's disease (AD), inflammatory bowel disease, arthritis, cardiovascular disease, NASH, type 2 diabetes, multiple sclerosis and chronic kidney disease.