Indian firm Marion Biotech used toxic industrial-grade ingredient in syrup: Sources
India directed drug manufacturers to stop using propylene glycol sourced from the Delhi-based firm that supplied the ingredient to Marion Biotech, whose cough syrups were linked to deaths of 19 children in Uzbekistan, according to a government document seen by Reuters.
Nicotine-based e-cigarettes come in a wide array of candy and fruit flavors. Many of them deliver amped-up forms of nicotine beyond what traditional cigarettes contain. Their allure is reflected in the latest National Youth Tobacco Survey, which found that more than 2 million middle and high school students are regular e-cigarette users. Unfortunately, the explosive growth of these products has outpaced their regulation and oversight, which leaves most of their ingredients a mystery.
A decisive push by the Chinese government to root out polluting industries across the country is sending shock waves through the Indian pharmaceutical sector that depends heavily on active pharmaceutical ingredients (APIs) imported from China. The price of some APIs -- raw materials required for making finished drugs -- has gone up by around 40 per cent in the last four months in the Indian market and drug manufacturers, especially small and medium enterprises (SMEs), are struggling to fulfill their contractual obligations owing to steep rise in production cost, it is learnt.
Our objectives were to explore the possibility of avoiding neonatal exposure to potentially harmful excipients of interest (EOI)—parabens, polysorbate 80, propylene glycol, benzoates, saccharin sodium, sorbitol and ethanol—through product substitution in Europe.
The STEP stands for Safety and Toxicity of Excipients for Paediatrics. The STEP database is a user-designed free resource that compiles the safety and toxicity information of excipients that is manually extracted from selected information sources. Three tier quality control procedures are implemented from information retrieval level to entry of the specific data in the database.