In-licensed potential best-in-class pan-RAS molecular glue ERAS-0015 and potential first-in-class pan-KRAS inhibitor ERAS-4001 with a goal of expanding treatment options across RAS-driven tumors ...
Naporafenib is a potential first-in-class and best-in-class pan-RAF inhibitor in multiple RAS/MAPK pathway-driven tumors Initial SEACRAFT-1 Phase 1b combination data in RAS Q61X solid tumors expected...
Erasca Announces Publication of Promising Clinical Data Supporting the Therapeutic Potential of Naporafenib in Combination with Trametinib in NRAS-Mutant Melanoma
In the mid-stage trial, 47% of the patients that were given the two drugs Tafinlar and Mekinist saw their tumours shrink, far above a rate of 11% in a comparative group of participants on standard chemotherapy, the drugmaker said on Monday.
Based on unprecedented progression-free survival results, Tafinlar (dabrafenib) + Mekinist (trametinib) confirmed as standard-of-care, targeted therapy for advanced BRAF-mutated melanoma1-4
NICE has announced its recommendation of Bristol-Myers Squibb’s blockbuster immunotherapy drug Opdivo (nivolumab) for the treatment of two non-small cell lung cancer (NSCLC) indications in the second-line, it has emerged.
Basel, September 16, 2020 — Novartis announced previously reported data from the Phase III COMBI-AD study were published today in The New England Journal of Medicine. The study shows more than half of high-risk patients with resected, stage III BRAF V600-mutated melanoma treated with Tafinlar® (dabrafenib) + Mekinist® (trametinib) were alive and relapse-free at 5 years1. Research suggests the majority of relapses in high-risk stage III melanoma generally occur within 5 years1,2.
Novartis has reported data from the Phase III COMBI-i clinical trial of spartalizumab (PDR001) in combination with Tafinlar (dabrafenib) and Mekinist (trametinib) to treat cutaneous melanoma.
Novartis has announced that its investigational immunotherapy spartalizumab in combination with Tafinlar (dabrafenib) and Mekinist (trametinib) failed to improve progression-free survival in patients with advanced melanoma.