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    Belumosudil Mesylate

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    Msn Organics Private Ltd

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    Msn Organics Private Ltd

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    DMF Review : N/A

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    DMF Number : 40514

    Submission : 2024-09-29

    Status : Active

    Type : II

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    Looking for 911417-87-3 / Belumosudil API manufacturers, exporters & distributors?

    Belumosudil manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Belumosudil API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Belumosudil manufacturer or Belumosudil supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Belumosudil manufacturer or Belumosudil supplier.

    PharmaCompass also assists you with knowing the Belumosudil API Price utilized in the formulation of products. Belumosudil API Price is not always fixed or binding as the Belumosudil Price is obtained through a variety of data sources. The Belumosudil Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Belumosudil

    Synonyms

    911417-87-3, Slx-2119, Kd-025, Kd025, Rock inhibitor 2, Rezurock

    Cas Number

    911417-87-3

    Unique Ingredient Identifier (UNII)

    834YJF89WO

    About Belumosudil

    Belumosudil is an orally bioavailable inhibitor of Rho-associated coiled-coil kinase 2 (ROCK2; ROCK-II), with potential immunomodulating activity. Upon oral administration, belumosudil binds to and inhibits the serine/threonine kinase activity of ROCK2. This inhibits ROCK2-mediated signal transduction pathways and modulates various pro- and anti-inflammatory immune cell responses through the regulation of signal transducer and activator of transcription 3 and 5 (STAT3/STAT5) phosphorylation. This downregulates pro-inflammatory Th17 cells and increases regulatory T (Treg) cells. Belumosudil also inhibits ROCK2-mediated fibrotic processes, including stress fiber formation, myofibroblast activation and pro-fibrotic gene transcription. ROCK2 is upregulated in various diseases, including various fibrotic, neurodegenerative and autoimmune diseases.

    Belumosudil Mesylate Manufacturers

    A Belumosudil Mesylate manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Belumosudil Mesylate, including repackagers and relabelers. The FDA regulates Belumosudil Mesylate manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Belumosudil Mesylate API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Belumosudil Mesylate manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Belumosudil Mesylate Suppliers

    A Belumosudil Mesylate supplier is an individual or a company that provides Belumosudil Mesylate active pharmaceutical ingredient (API) or Belumosudil Mesylate finished formulations upon request. The Belumosudil Mesylate suppliers may include Belumosudil Mesylate API manufacturers, exporters, distributors and traders.

    click here to find a list of Belumosudil Mesylate suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Belumosudil Mesylate USDMF

    A Belumosudil Mesylate DMF (Drug Master File) is a document detailing the whole manufacturing process of Belumosudil Mesylate active pharmaceutical ingredient (API) in detail. Different forms of Belumosudil Mesylate DMFs exist exist since differing nations have different regulations, such as Belumosudil Mesylate USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Belumosudil Mesylate DMF submitted to regulatory agencies in the US is known as a USDMF. Belumosudil Mesylate USDMF includes data on Belumosudil Mesylate's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Belumosudil Mesylate USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Belumosudil Mesylate suppliers with USDMF on PharmaCompass.

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.